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Cancer Vaccines

Overview of attention for book
Cover of 'Cancer Vaccines'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Single-Step Antigen Loading and Maturation of Dendritic Cells Through mRNA Electroporation of a Tumor-Associated Antigen and a TriMix of Costimulatory Molecules
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    Chapter 2 Generation of Multiple Peptide Cocktail-Pulsed Dendritic Cells as a Cancer Vaccine
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    Chapter 3 Pulsing Dendritic Cells with Whole Tumor Cell Lysates
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    Chapter 4 Antigen Trapping by Dendritic Cells for Antitumor Therapy
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    Chapter 5 Ex Vivo Loading of Autologous Dendritic Cells with Tumor Antigens
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    Chapter 6 Tumor antigen-/cytokine-pulsed dendritic cells in therapy against lymphoma.
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    Chapter 7 Dendritic Cells Primed with Protein–Protein Fusion Adjuvant
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    Chapter 8 Antigen-specific mRNA transfection of autologous dendritic cells.
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    Chapter 9 Electroporation of dendritic cells with autologous total RNA from tumor material.
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    Chapter 10 Dendritic Cells Transfected with Adenoviral Vectors as Vaccines
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    Chapter 11 Genetic Modification of Dendritic Cells with RNAi.
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    Chapter 12 Fast Monocyte-Derived Dendritic Cell-Based Immunotherapy
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    Chapter 13 Intratumoral Injection of BCG-CWS-Pretreated Dendritic Cells Following Tumor Cryoablation
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    Chapter 14 Exploiting the CD1d-iNKT Cell Axis for Potentiation of DC-Based Cancer Vaccines.
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    Chapter 15 Modification of T lymphocytes to express tumor antigens.
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    Chapter 16 Genetic modification of mouse effector and helper T lymphocytes expressing a chimeric antigen receptor.
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    Chapter 17 Genetic modification of cytotoxic T lymphocytes to express cytokine receptors.
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    Chapter 18 Monitoring the Frequency and Function of Regulatory T Cells and Summary of the Approaches Currently Used to Inhibit Regulatory T Cells in Cancer Patients
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    Chapter 19 Cytokine activation of natural killer cells.
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    Chapter 20 Loading of Acute Myeloid Leukemia Cells with Poly(I:C) by Electroporation
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    Chapter 21 Autologous Tumor Cells Engineered to Express Bacterial Antigens
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    Chapter 22 Tumor Cell Transformation Using Antisense Oligonucleotide
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    Chapter 23 The direct display of costimulatory proteins on tumor cells as a means of vaccination for cancer immunotherapy.
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    Chapter 24 Cloning variable region genes of clonal lymphoma immunoglobulin for generating patient-specific idiotype DNA vaccine.
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    Chapter 25 Heat Shock Proteins Purified from Autologous Tumors Using Antibody-Based Affinity Chromatography
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    Chapter 26 Invariant Chain-Peptide Fusion Vaccine Using HER-2/neu
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    Chapter 27 TLR-9 Agonist Immunostimulatory Sequence Adjuvants Linked to Cancer Antigens.
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    Chapter 28 Production of Multiple CTL Epitopes from Multiple Tumor-Associated Antigens.
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    Chapter 29 Preparation of Polypeptides Comprising Multiple TAA Peptides.
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    Chapter 30 Idiotype Vaccine Production Using Hybridoma Technology
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    Chapter 31 Preparation of Cancer-Related Peptide Cocktails that Target Heterogeneously Expressed Antigens
  33. Altmetric Badge
    Chapter 32 Making an Avipoxvirus Encoding a Tumor-Associated Antigen and a Costimulatory Molecule
  34. Altmetric Badge
    Chapter 33 Bacterial vectors for the delivery of tumor antigens.
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    Chapter 34 Preparation of Peptide microspheres using tumor antigen-derived peptides.
  36. Altmetric Badge
    Chapter 35 Production of antigen-loaded biodegradable nanoparticles and uptake by dendritic cells.
  37. Altmetric Badge
    Chapter 36 Development of Plasmid–Lipid Complexes for Direct Intratumoral Injection
  38. Altmetric Badge
    Chapter 37 The use of dendritic cells for Peptide-based vaccination in cancer immunotherapy.
  39. Altmetric Badge
    Chapter 38 Advances in host and vector development for the production of plasmid DNA vaccines.
  40. Altmetric Badge
    Chapter 39 Challenges facing the development of cancer vaccines.
  41. Altmetric Badge
    Chapter 40 Future of cancer vaccines.
Attention for Chapter 16: Genetic modification of mouse effector and helper T lymphocytes expressing a chimeric antigen receptor.
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

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Chapter title
Genetic modification of mouse effector and helper T lymphocytes expressing a chimeric antigen receptor.
Chapter number 16
Book title
Cancer Vaccines
Published in
Methods in molecular biology, February 2014
DOI 10.1007/978-1-4939-0345-0_16
Pubmed ID
Book ISBNs
978-1-4939-0344-3, 978-1-4939-0345-0
Authors

John LB, Chee TM, Gilham DE, Darcy PK, John, Liza B., Chee, Tess M., Gilham, David E., Darcy, Phillip K., Liza B. John, Tess M. Chee, David E. Gilham, Phillip K. Darcy

Abstract

Genetic modification of primary mouse T cells with chimeric antigen receptors (CAR) has emerged as an important tool for optimizing adoptive T cell immunotherapy strategies. However, limitations in current protocols for generating highly pure and sufficient numbers of enriched effector and helper CAR(+) T cell subsets remain problematic. Here, we describe a new retroviral transduction protocol for successfully generating transduced CD8(+) and CD4(+) T lymphocytes for in vitro and in vivo characterization.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 7%
Unknown 14 93%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 3 20%
Student > Ph. D. Student 3 20%
Student > Bachelor 2 13%
Student > Master 2 13%
Researcher 2 13%
Other 0 0%
Unknown 3 20%
Readers by discipline Count As %
Medicine and Dentistry 4 27%
Agricultural and Biological Sciences 3 20%
Immunology and Microbiology 3 20%
Pharmacology, Toxicology and Pharmaceutical Science 1 7%
Unknown 4 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 July 2023.
All research outputs
#4,506,192
of 22,755,127 outputs
Outputs from Methods in molecular biology
#1,289
of 13,089 outputs
Outputs of similar age
#55,296
of 307,489 outputs
Outputs of similar age from Methods in molecular biology
#55
of 637 outputs
Altmetric has tracked 22,755,127 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,089 research outputs from this source. They receive a mean Attention Score of 3.3. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 307,489 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 637 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.