Chapter title |
Dysregulation of c-myc in multiple myeloma.
|
---|---|
Chapter number | 29 |
Book title |
C-Myc in B-Cell Neoplasia
|
Published in |
Current topics in microbiology and immunology, January 1997
|
DOI | 10.1007/978-3-642-60801-8_29 |
Pubmed ID | |
Book ISBNs |
978-3-64-264560-0, 978-3-64-260801-8
|
Authors |
Kuehl, W M, Brents, L A, Chesi, M, Huppi, K, Bergsagel, P L, Kuehl, W. M., Brents, L. A., Chesi, M., Huppi, K., Bergsagel, P. L. |
Abstract |
Translocation of c-myc to IgH switch regions, or less frequently to one of the IgL loci, is essentially an invariant event in murine plasmacytomas. This results in dysregulation of c-myc, manifested by selective expression of the translocated allele. Human multiple myeloma (MM) has a similarly high incidence of translocations involving IgH switch regions, but c-myc is infrequently involved as a partner in these translocations. However, in screening a panel of 20 MM cell lines, we identified six lines containing two genetically distinguishable c-myc alleles. For these six informative lines (and the corresponding tumor for one line) there is selective expression of one c-myc allele despite the apparent absence of translocation, DNA rearrangement, or amplification involving c-myc. This result suggests frequent tumor specific cis-dysregulation of c-myc in MM by a presently unknown mechanism. |
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