Chapter title |
Investigation of aberrant translational control of c-myc in cell lines derived from patients with multiple myeloma.
|
---|---|
Chapter number | 28 |
Book title |
C-Myc in B-Cell Neoplasia
|
Published in |
Current topics in microbiology and immunology, January 1997
|
DOI | 10.1007/978-3-642-60801-8_28 |
Pubmed ID | |
Book ISBNs |
978-3-64-264560-0, 978-3-64-260801-8
|
Authors |
Willis, A E, Paulin, F E, West, M J, Whitney, R L, Willis, A. E., Paulin, F. E. M., West, M. J., Whitney, R. L. |
Abstract |
In cell lines derived from patients with multiple myeloma (MM) we have found an elevation in the amount of the c-myc protein which is not accompanied by an increase in the level of mRNA or a change in the half-life of the protein. There is a 3.4 fold enhancement in the degree of association of the c-myc message with polysomes. This is not accompanied by an alteration in polysome size or a change in the transit time of the c-myc mRNA on the polysomes thus suggesting that there is in increase in the degree of mobilisation of the c-myc message. Sequencing of the c-myc 5'UTR has revealed the presence of a mutation in all the MM cell lines studied and we demonstrate that this mutation causes altered binding of cellular proteins to this RNA species. |
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