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Mendeley readers
Chapter title |
Biotransformation of DHEA into 7α,15α-diOH-DHEA
|
---|---|
Chapter number | 20 |
Book title |
Microbial Steroids
|
Published in |
Methods in molecular biology, July 2017
|
DOI | 10.1007/978-1-4939-7183-1_20 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7182-4, 978-1-4939-7183-1
|
Authors |
Hui Li, Jin Sun, Zhenghong Xu |
Abstract |
3β,7α,15α-Trihydroxy-5-androsten-17-one (7α,15α-diOH-DHEA) is a key intermediate of the novel oral contraceptive "Yasmin" (widely used in birth control pills and postmenopausal hormone replacement therapy pills; the active ingredient is drospirenone). It can be synthesized from dehydroepiandrosterone (DHEA) by microbial dihydroxylation at the C7 and C15 positions. Here we describe the method of bioconversion from DHEA into 7α,15α-diOH-DHEA by Colletotrichum lini. Using 6 g/L DHEA as a substrate, the DHEA conversion and the 7α,15α-diOH-DHEA molar yield were 72.6% and 51.2%, respectively. |
Mendeley readers
The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 10 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 3 | 30% |
Student > Bachelor | 2 | 20% |
Student > Master | 2 | 20% |
Professor | 1 | 10% |
Student > Ph. D. Student | 1 | 10% |
Other | 0 | 0% |
Unknown | 1 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 2 | 20% |
Biochemistry, Genetics and Molecular Biology | 2 | 20% |
Immunology and Microbiology | 2 | 20% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 10% |
Chemistry | 1 | 10% |
Other | 0 | 0% |
Unknown | 2 | 20% |