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Taurine 8

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Cover of 'Taurine 8'

Table of Contents

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    Book Overview
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    Chapter 1 Taurine, Glutathione and Bioenergetics
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    Chapter 2 Molybdenum Cofactor Deficiency: Metabolic Link Between Taurine and S-Sulfocysteine
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    Chapter 3 Taurine and chinese traditional medicine accelerate alcohol metabolism in mice.
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    Chapter 4 Lethality of Taurine and Alcohol Coadministration in Mice
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    Chapter 5 The effect of long-term taurine supplementation and fructose feeding on glucose and lipid homeostasis in wistar rats.
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    Chapter 6 Effect of Taurine Feeding on Bone Mineral Density and Bone Markers in Rats
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    Chapter 7 The effects of bisphosphonates on taurine transport in retinal capillary endothelial cells under high glucose conditions.
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    Chapter 8 Perinatal Taurine Imbalance Alters the Interplay of Renin–Angiotensin System and Estrogen on Glucose–Insulin Regulation in Adult Female Rats
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    Chapter 9 Reduced Placental Taurine Transporter (TauT) Activity in Pregnancies Complicated by Pre-eclampsia and Maternal Obesity.
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    Chapter 10 Taurine 8
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    Chapter 11 Positive Correlation Between Serum Taurine and Adiponectin Levels in High-Fat Diet-Induced Obesity Rats
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    Chapter 12 Relationship Among Serum Taurine, Serum Adipokines, and Body Composition During 8-Week Human Body Weight Control Program
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    Chapter 13 Dietary taurine and nutrient intake and dietary quality by alcohol consumption level in korean male college students.
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    Chapter 14 Taurine Supplementation Restores Insulin Secretion and Reduces ER Stress Markers in Protein-Malnourished Mice.
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    Chapter 15 Taurine as a Marker for the Identification of Natural Calculus Bovis and Its Substitutes
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    Chapter 16 Taurine Deficiency and MELAS Are Closely Related Syndromes
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    Chapter 17 Antioxidant and DNA Protection Effects of Taurine by Electron Spin Resonance Spectroscopy
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    Chapter 18 Additional Effects of Taurine on the Benefits of BCAA Intake for the Delayed-Onset Muscle Soreness and Muscle Damage Induced by High-Intensity Eccentric Exercise
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    Chapter 19 Taurine Enhances Anticancer Activity of Cisplatin in Human Cervical Cancer Cells
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    Chapter 20 Comparative Evaluation of the Effects of Taurine and Thiotaurine on Alterations of the Cellular Redox Status and Activities of Antioxidant and Glutathione-Related Enzymes by Acetaminophen in the Rat
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    Chapter 21 Effects of Taurine on Myocardial cGMP/cAMP Ratio, Antioxidant Ability, and Ultrastructure in Cardiac Hypertrophy Rats Induced by Isoproterenol
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    Chapter 22 Protective Effect of Taurine on Triorthocresyl Phosphate (TOCP)-Induced Cytotoxicity in C6 Glioma Cells
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    Chapter 23 The mechanism of taurine protection against endoplasmic reticulum stress in an animal stroke model of cerebral artery occlusion and stroke-related conditions in primary neuronal cell culture.
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    Chapter 24 Relationship Among Self-Reported Fatigue, Dietary Taurine Intake, and Dietary Habits in Korean College Students
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    Chapter 25 Simulative Evaluation of Taurine Against Alopecia Caused by Stress in Caenorhabditis elegans
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    Chapter 26 Protective Effect of Taurine on the Decreased Biogenic Amine Neurotransmitter Levels in the Brain of Mice Exposed to Arsenic
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    Chapter 27 Differential Regulation of TauT by Calcitriol and Retinoic Acid via VDR/RXR in LLC-PK1 and MCF-7 Cells
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    Chapter 28 Knockdown of TauT Expression Impairs Human Embryonic Kidney 293 Cell Development
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    Chapter 29 The role of taurine on skeletal muscle cell differentiation.
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    Chapter 30 Taurine and fish development: insights for the aquaculture industry.
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    Chapter 31 Effect of Dietary Taurine and Arginine Supplementation on Bone Mineral Density in Growing Female Rats
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    Chapter 32 Taurine Enhances the Sexual Response and Mating Ability in Aged Male Rats
Attention for Chapter 7: The effects of bisphosphonates on taurine transport in retinal capillary endothelial cells under high glucose conditions.
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Chapter title
The effects of bisphosphonates on taurine transport in retinal capillary endothelial cells under high glucose conditions.
Chapter number 7
Book title
Taurine 8
Published in
Advances in experimental medicine and biology, January 2013
DOI 10.1007/978-1-4614-6093-0_7
Pubmed ID
Book ISBNs
978-1-4614-6092-3, 978-1-4614-6093-0
Authors

Na-Young Lee, Young-Sook Kang, Lee, Na-Young, Kang, Young-Sook

Abstract

Diabetic retinopathy (DR) is a major cause of blindness in diabetic patients. Elevated glucose and vascular endothelial growth factor (VEGF) in retina can trigger many of the retinal vascular changes caused by diabetes and DR. Recently, bisphosphonates, antiosteoporosis drugs, have been reported to have anti-angiogenic effect by decreasing VEGF. Taurine has several biological processes such as osmoregulation and antioxidation in retina. Therefore, the purpose of this study is to clarify the regulation of taurine transport activity by high glucose concentration and the effect of inhibitors for VEGF function, bisphosphonates, on taurine transport under high glucose condition using TR-iBRB cell lines as an in vitro model of inner blood-retinal barrier (iBRB). As a result, by exposing TR-iBRB cells to high glucose for 48 h, [(3)H]taurine uptake was decreased continuously. [(3)H]Taurine uptake was increased significantly by pretreatment of alendronate and pamidronate compared with the values for high glucose. Increased [(3)H]taurine uptake by pretreatment of alendronate and pamidronate was significantly reduced by mevalonate pathway intermediates, geranylgeraniol (GGOH). In conclusion, taurine transport through the iBRB under high glucose condition can be regulated by bisphosphonates via mevalonate pathway. Therefore, we suggest that bisphosphonates could have the beneficial effects on DR by regulation of taurine contents in retina.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 31%
Student > Postgraduate 2 15%
Student > Master 2 15%
Student > Ph. D. Student 1 8%
Other 1 8%
Other 0 0%
Unknown 3 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 31%
Medicine and Dentistry 3 23%
Neuroscience 2 15%
Pharmacology, Toxicology and Pharmaceutical Science 1 8%
Unknown 3 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 February 2013.
All research outputs
#15,335,826
of 17,351,915 outputs
Outputs from Advances in experimental medicine and biology
#2,897
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Outputs of similar age
#219,630
of 256,745 outputs
Outputs of similar age from Advances in experimental medicine and biology
#124
of 159 outputs
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