| Chapter title |
Comparative Studies of Actin- and Rho-Specific ADP-Ribosylating Toxins: Insight from Structural Biology
|
|---|---|
| Chapter number | 23 |
| Book title |
The Actin Cytoskeleton and Bacterial Infection
|
| Published in |
Current topics in microbiology and immunology, January 2016
|
| DOI | 10.1007/82_2016_23 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-950046-1, 978-3-31-950047-8
|
| Authors |
Hideaki Tsuge, Toshiharu Tsurumura, Akiyuki Toda, Haruka Murata, Waraphan Toniti, Toru Yoshida |
| Abstract |
Mono-ADP-ribosylation is a major post-translational modification performed by bacterial toxins, which transfer an ADP-ribose moiety to a substrate acceptor residue. Actin- and Rho-specific ADP-ribosylating toxins (ARTs) are typical ARTs known to have very similar tertiary structures but totally different targets. Actin-specific ARTs are the A components of binary toxins, ADP-ribosylate actin at Arg177, leading to the depolymerization of the actin cytoskeleton. On the other hand, C3-like exoenzymes are Rho-specific ARTs, ADP-ribosylate Rho GTPases at Asn41, exerting an indirect effect on the actin cytoskeleton. This review focuses on the differences and similarities of actin- and Rho-specific ARTs, especially with respect to their substrate recognition and cell entry mechanisms, based on structural studies. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 4 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 1 | 25% |
| Student > Doctoral Student | 1 | 25% |
| Unknown | 2 | 50% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 1 | 25% |
| Engineering | 1 | 25% |
| Unknown | 2 | 50% |