| Chapter title |
Toolbox for Protein Structure Prediction
|
|---|---|
| Chapter number | 23 |
| Book title |
Yeast Cytokinesis
|
| Published in |
Methods in molecular biology, January 2016
|
| DOI | 10.1007/978-1-4939-3145-3_23 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-3144-6, 978-1-4939-3145-3
|
| Authors |
Roche, Daniel Barry, McGuffin, Liam James, Daniel Barry Roche, Liam James McGuffin |
| Editors |
Alberto Sanchez-Diaz, Pilar Perez |
| Abstract |
Protein tertiary structure prediction algorithms aim to predict, from amino acid sequence, the tertiary structure of a protein. In silico protein structure prediction methods have become extremely important, as in vitro-based structural elucidation is unable to keep pace with the current growth of sequence databases due to high-throughput next-generation sequencing, which has exacerbated the gaps in our knowledge between sequences and structures.Here we briefly discuss protein tertiary structure prediction, the biennial competition for the Critical Assessment of Techniques for Protein Structure Prediction (CASP) and its role in shaping the field. We also discuss, in detail, our cutting-edge web-server method IntFOLD2-TS for tertiary structure prediction. Furthermore, we provide a step-by-step guide on using the IntFOLD2-TS web server, along with some real world examples, where the IntFOLD server can and has been used to improve protein tertiary structure prediction and aid in functional elucidation. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Pakistan | 1 | 5% |
| Unknown | 19 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 4 | 20% |
| Researcher | 4 | 20% |
| Student > Bachelor | 3 | 15% |
| Professor | 2 | 10% |
| Student > Ph. D. Student | 2 | 10% |
| Other | 3 | 15% |
| Unknown | 2 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 40% |
| Agricultural and Biological Sciences | 3 | 15% |
| Medicine and Dentistry | 2 | 10% |
| Computer Science | 1 | 5% |
| Chemical Engineering | 1 | 5% |
| Other | 2 | 10% |
| Unknown | 3 | 15% |