Chapter title |
DNAhsp65 Vaccine as Therapy against Paracoccidioidomycosis
|
---|---|
Chapter number | 7 |
Book title |
Vaccines for Invasive Fungal Infections
|
Published in |
Methods in molecular biology, June 2017
|
DOI | 10.1007/978-1-4939-7104-6_7 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7103-9, 978-1-4939-7104-6
|
Authors |
Ribeiro, Alice M., Amaral, André C., Felipe, Maria Sueli S., Bocca, Anamelia L., Alice M. Ribeiro, André C. Amaral, Maria Sueli S. Felipe, Anamelia L. Bocca |
Editors |
Markus Kalkum, Margarita Semis |
Abstract |
The conventional treatment for fungal diseases usually shows long periods of therapy and the high frequency of relapses and sequels. New strategies of the treatment are necessary. We have shown that the Mycobacterium leprae HSP65 gene can be successfully used as therapy against murine Paracoccidioidomycosis (PCM). Here, we described the methodology of DNAhsp65 immunotherapy in mice infected with the dimorphic fungus Paracoccidioides brasiliensis, one of PCM agent, evaluating cytokines levels, fungal burden, and lung injury. Our results provide a new prospective on the immunotherapy of mycosis. |
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United Kingdom | 1 | 100% |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 9 | 100% |
Demographic breakdown
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Student > Master | 2 | 22% |
Student > Postgraduate | 2 | 22% |
Student > Bachelor | 1 | 11% |
Professor > Associate Professor | 1 | 11% |
Other | 1 | 11% |
Other | 0 | 0% |
Unknown | 2 | 22% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 2 | 22% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 11% |
Engineering | 1 | 11% |
Unknown | 3 | 33% |