| Chapter title |
Signalling Pathways Controlling Cellular Actin Organization
|
|---|---|
| Chapter number | 35 |
| Book title |
The Actin Cytoskeleton
|
| Published in |
Handbook of experimental pharmacology, January 2016
|
| DOI | 10.1007/164_2016_35 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-946369-8, 978-3-31-946371-1
|
| Authors |
Anika Steffen, Theresia E. B. Stradal, Klemens Rottner |
| Editors |
Brigitte M. Jockusch |
| Abstract |
The actin cytoskeleton is essential for morphogenesis and virtually all types of cell shape changes. Reorganization is per definition driven by continuous disassembly and re-assembly of actin filaments, controlled by major, ubiquitously operating machines. These are specifically employed by the cell to tune its activities in accordance with respective environmental conditions or to satisfy specific needs.Here we sketch some fundamental signalling pathways established to contribute to the reorganization of specific actin structures at the plasma membrane. Rho-family GTPases are at the core of these pathways, and dissection of their precise contributions to actin reorganization in different cell types and tissues will thus continue to improve our understanding of these important signalling nodes. Furthermore, we will draw your attention to the emerging theme of actin reorganization on intracellular membranes, its functional relation to Rho-GTPase signalling, and its relevance for the exciting phenomenon autophagy. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 37 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 30% |
| Student > Master | 4 | 11% |
| Student > Bachelor | 4 | 11% |
| Researcher | 3 | 8% |
| Other | 2 | 5% |
| Other | 4 | 11% |
| Unknown | 9 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 13 | 35% |
| Immunology and Microbiology | 3 | 8% |
| Engineering | 3 | 8% |
| Agricultural and Biological Sciences | 2 | 5% |
| Medicine and Dentistry | 2 | 5% |
| Other | 4 | 11% |
| Unknown | 10 | 27% |