Chapter 16 Nonclinical Safety and Toxicology

Chapter 17 In Vivo Target Validation Using Biological Molecules in Drug Development

Chapter 18 Implementation and Use of State-of-the-Art, Cell-Based In Vitro Assays

Chapter 19 Sources for Leads: Natural Products and Libraries

Chapter 20 Trends in Modern Drug Discovery

Chapter 21 Modeling and Simulation of In Vivo Drug Effects

Chapter 22 Translational In Vivo Models for Women’s Health: The Nonhuman Primate Endometrium—A Predictive Model for Assessing Steroid Receptor Modulators

Chapter 23 Using Cheminformatics in Drug Discovery

Chapter 24 New Approaches to Drug Discovery

Chapter 25 High-Throughput Synthesis of Diverse Compound Collections for Lead Discovery and Optimization

Chapter 26 Pharmacokinetics in Drug Discovery: An Exposure-Centred Approach to Optimising and Predicting Drug Efficacy and Safety

Chapter 27 Functional Genomics in Pharmaceutical Drug Discovery.

Chapter 29 Predictive In Vivo Models for Oncology

Chapter 30 New Compound Classes: Protein–Protein Interactions

Chapter 31 Translational In Vivo Models for Cardiovascular Diseases.