Chapter title |
High-Throughput Synthesis of Diverse Compound Collections for Lead Discovery and Optimization
|
---|---|
Chapter number | 25 |
Book title |
New Approaches to Drug Discovery
|
Published in |
Handbook of experimental pharmacology, September 2015
|
DOI | 10.1007/164_2015_25 |
Pubmed ID | |
Book ISBNs |
978-3-31-928912-0, 978-3-31-928914-4
|
Authors |
C. Rademacher, P. H. Seeberger, Rademacher, C., Seeberger, P. H. |
Abstract |
Small-molecule intervention of protein function is one central dogma of drug discovery. The generation of small-molecule libraries fuels the discovery pipeline at many stages and thereby resembles a key aspect of this endeavor. High-throughput synthesis is a major source for compound libraries utilized in academia and industry, seeking new chemical modulators of pharmacological targets. Here, we discuss the crucial factors of library design strategies from the perspective of synthetic chemistry, giving a brief historic background and a summary of current approaches. Simple measures of success of a high-throughput synthesis such as quantity or diversity have long been discarded and replaced by more integrated measures. Case studies are presented and put into context to highlight the cross-connectivity of the various stages of the drug discovery process. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 14 | 100% |
Demographic breakdown
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Student > Ph. D. Student | 6 | 43% |
Researcher | 2 | 14% |
Other | 1 | 7% |
Student > Bachelor | 1 | 7% |
Lecturer > Senior Lecturer | 1 | 7% |
Other | 0 | 0% |
Unknown | 3 | 21% |
Readers by discipline | Count | As % |
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Chemistry | 7 | 50% |
Chemical Engineering | 3 | 21% |
Medicine and Dentistry | 1 | 7% |
Unknown | 3 | 21% |