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ATM Kinase

Overview of attention for book
Cover of 'ATM Kinase'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Assaying Radiosensitivity of Ataxia-Telangiectasia
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    Chapter 2 Assaying for Radioresistant DNA Synthesis, the Hallmark Feature of the Intra-S-Phase Checkpoint Using a DNA Fiber Technique
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    Chapter 3 ATM Gene Mutation Detection Techniques and Functional Analysis
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    Chapter 4 An HTRF® Assay for the Protein Kinase ATM
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    Chapter 5 ATM Kinase Inhibitors: HTS Cellular Imaging Assay Using Cellomics™ ArrayScan VTI Platform
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    Chapter 6 Image-Based High Content Screening: Automating the Quantification Process for DNA Damage-Induced Foci
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    Chapter 7 Analyzing ATM Function by Electroporation of Endonucleases and Immunofluorescence Microscopy
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    Chapter 8 Quantitative and Dynamic Imaging of ATM Kinase Activity by Bioluminescence Imaging
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    Chapter 9 Zn(II)–Phos-Tag SDS-PAGE for Separation and Detection of a DNA Damage-Related Signaling Large Phosphoprotein
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    Chapter 10 Identification of ATM Protein Kinase Phosphorylation Sites by Mass Spectrometry
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    Chapter 11 Studies of ATM Kinase Activity Using Engineered ATM Sensitive to ATP Analogues (ATM-AS)
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    Chapter 12 Functional Characterization of ATM Kinase Using Acetylation-Specific Antibodies
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    Chapter 13 Identification of ATM-Interacting Proteins by Co-immunoprecipitation and Glutathione-S-Transferase (GST) Pull-Down Assays
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    Chapter 14 ATM Activation and H2AX Phosphorylation Induced by Genotoxic Agents Assessed by Flow- and Laser Scanning Cytometry
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    Chapter 15 Peptide Immunoaffinity Enrichment with Targeted Mass Spectrometry: Application to Quantification of ATM Kinase Phospho-Signaling
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    Chapter 16 Mass Spectrometry-Based Proteomics for Quantifying DNA Damage-Induced Phosphorylation
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    Chapter 17 Statistical Analysis of ATM-Dependent Signaling in Quantitative Mass Spectrometry Phosphoproteomics
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    Chapter 18 ChIP Technique to Study Protein Dynamics at Defined DNA Double Strand Breaks
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    Chapter 19 Studies of the DNA Damage Response by Using the Lac Operator/Repressor (LacO/LacR) Tethering System
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    Chapter 20 Imaging of Fluorescently Tagged ATM Kinase at the Sites of DNA Double Strand Breaks
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    Chapter 21 Live Cell Imaging to Study Real-Time ATM-Mediated Recruitment of DNA Repair Complexes to Sites of Ionizing Radiation-Induced DNA Damage
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    Chapter 22 Analyzing Heterochromatic DNA Double Strand Break (DSB) Repair in Response to Ionizing Radiation
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    Chapter 23 Phenotypic Analysis of ATM Protein Kinase in DNA Double-Strand Break Formation and Repair
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    Chapter 24 Monitoring DNA Repair Consequences of ATM Signaling Using Simultaneous Fluorescent Readouts
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    Chapter 25 Noncanonical ATM Activation and Signaling in Response to Transcription-Blocking DNA Damage
  27. Altmetric Badge
    Chapter 26 Study of ATM Phosphorylation by Cdk5 in Neuronal Cells
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    Chapter 27 DNA Damage Response in Human Stem Cells and Neural Descendants
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    Chapter 28 A Patient-Specific Stem Cell Model to Investigate the Neurological Phenotype Observed in Ataxia-Telangiectasia
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    Chapter 29 Lentiviral Reprogramming of A-T Patient Fibroblasts to Induced Pluripotent Stem Cells
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    Chapter 30 Monitoring the ATM-Mediated DNA Damage Response in the Cerebellum Using Organotypic Cultures
Attention for Chapter 27: DNA Damage Response in Human Stem Cells and Neural Descendants
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Chapter title
DNA Damage Response in Human Stem Cells and Neural Descendants
Chapter number 27
Book title
ATM Kinase
Published in
Methods in molecular biology, January 2017
DOI 10.1007/978-1-4939-6955-5_27
Pubmed ID
Book ISBNs
978-1-4939-6953-1, 978-1-4939-6955-5, 978-1-4939-6953-1, 978-1-4939-6955-5
Authors

Jason M. Beckta, Bret R. Adams, Kristoffer Valerie Ph.D., Kristoffer Valerie, Beckta, Jason M., Adams, Bret R., Valerie, Kristoffer

Editors

Sergei V. Kozlov

Abstract

Glial cells are crucial for the normal function of neurons and are intricately involved in the pathogenesis of neurodegenerative diseases as well as neurologic malignancies. A deeper understanding of the mechanisms by which glial cells influence the development of such pathologies will undoubtedly lead to new and improved therapeutic approaches. Commercially available human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs), both of which can be differentiated into neural progenitors (NPs) and various neural cell lineages, have become widely used as sources for producing normal human central nervous system (CNS) cells. A better understanding of the DNA damage response (DDR) that occurs in these cells after therapeutic ionizing radiation (IR) and chemotherapy is essential for assessing the effects on healthy human brain.Neurodegenerative features associated with conditions such as ataxia telangiectasia and Nijmegen breakage syndrome highlight the importance of DNA double strand break (DSB) repair pathways in maintaining genomic integrity in cells of the CNS. Similarly, the development of brain tumors is also intricately linked to DNA repair. The importance of ATM and the other phosphatidylinositol 3-kinase-related kinase (PIKK) family members, ATR and DNA-PKcs, is not fully defined in either CNS developmental or pathological states. While their roles are relatively well established in the DDR of proliferating cells, our recent work has demonstrated that these processes exhibit spatiotemporal evolution during cell differentiation. This chapter discusses and explores various laboratory techniques for investigating the role of ATM in hESCs and differentiated neural cells.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 30%
Student > Ph. D. Student 2 20%
Student > Doctoral Student 1 10%
Researcher 1 10%
Student > Postgraduate 1 10%
Other 0 0%
Unknown 2 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 30%
Pharmacology, Toxicology and Pharmaceutical Science 1 10%
Computer Science 1 10%
Psychology 1 10%
Medicine and Dentistry 1 10%
Other 1 10%
Unknown 2 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 February 2018.
All research outputs
#13,551,243
of 22,971,207 outputs
Outputs from Methods in molecular biology
#3,649
of 13,142 outputs
Outputs of similar age
#212,652
of 421,094 outputs
Outputs of similar age from Methods in molecular biology
#325
of 1,074 outputs
Altmetric has tracked 22,971,207 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,142 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,094 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,074 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.