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ATM Kinase

Overview of attention for book
Cover of 'ATM Kinase'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Assaying Radiosensitivity of Ataxia-Telangiectasia
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    Chapter 2 Assaying for Radioresistant DNA Synthesis, the Hallmark Feature of the Intra-S-Phase Checkpoint Using a DNA Fiber Technique
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    Chapter 3 ATM Gene Mutation Detection Techniques and Functional Analysis
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    Chapter 4 An HTRF® Assay for the Protein Kinase ATM
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    Chapter 5 ATM Kinase Inhibitors: HTS Cellular Imaging Assay Using Cellomics™ ArrayScan VTI Platform
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    Chapter 6 Image-Based High Content Screening: Automating the Quantification Process for DNA Damage-Induced Foci
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    Chapter 7 Analyzing ATM Function by Electroporation of Endonucleases and Immunofluorescence Microscopy
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    Chapter 8 Quantitative and Dynamic Imaging of ATM Kinase Activity by Bioluminescence Imaging
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    Chapter 9 Zn(II)–Phos-Tag SDS-PAGE for Separation and Detection of a DNA Damage-Related Signaling Large Phosphoprotein
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    Chapter 10 Identification of ATM Protein Kinase Phosphorylation Sites by Mass Spectrometry
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    Chapter 11 Studies of ATM Kinase Activity Using Engineered ATM Sensitive to ATP Analogues (ATM-AS)
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    Chapter 12 Functional Characterization of ATM Kinase Using Acetylation-Specific Antibodies
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    Chapter 13 Identification of ATM-Interacting Proteins by Co-immunoprecipitation and Glutathione-S-Transferase (GST) Pull-Down Assays
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    Chapter 14 ATM Activation and H2AX Phosphorylation Induced by Genotoxic Agents Assessed by Flow- and Laser Scanning Cytometry
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    Chapter 15 Peptide Immunoaffinity Enrichment with Targeted Mass Spectrometry: Application to Quantification of ATM Kinase Phospho-Signaling
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    Chapter 16 Mass Spectrometry-Based Proteomics for Quantifying DNA Damage-Induced Phosphorylation
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    Chapter 17 Statistical Analysis of ATM-Dependent Signaling in Quantitative Mass Spectrometry Phosphoproteomics
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    Chapter 18 ChIP Technique to Study Protein Dynamics at Defined DNA Double Strand Breaks
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    Chapter 19 Studies of the DNA Damage Response by Using the Lac Operator/Repressor (LacO/LacR) Tethering System
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    Chapter 20 Imaging of Fluorescently Tagged ATM Kinase at the Sites of DNA Double Strand Breaks
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    Chapter 21 Live Cell Imaging to Study Real-Time ATM-Mediated Recruitment of DNA Repair Complexes to Sites of Ionizing Radiation-Induced DNA Damage
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    Chapter 22 Analyzing Heterochromatic DNA Double Strand Break (DSB) Repair in Response to Ionizing Radiation
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    Chapter 23 Phenotypic Analysis of ATM Protein Kinase in DNA Double-Strand Break Formation and Repair
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    Chapter 24 Monitoring DNA Repair Consequences of ATM Signaling Using Simultaneous Fluorescent Readouts
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    Chapter 25 Noncanonical ATM Activation and Signaling in Response to Transcription-Blocking DNA Damage
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    Chapter 26 Study of ATM Phosphorylation by Cdk5 in Neuronal Cells
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    Chapter 27 DNA Damage Response in Human Stem Cells and Neural Descendants
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    Chapter 28 A Patient-Specific Stem Cell Model to Investigate the Neurological Phenotype Observed in Ataxia-Telangiectasia
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    Chapter 29 Lentiviral Reprogramming of A-T Patient Fibroblasts to Induced Pluripotent Stem Cells
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    Chapter 30 Monitoring the ATM-Mediated DNA Damage Response in the Cerebellum Using Organotypic Cultures
Attention for Chapter 5: ATM Kinase Inhibitors: HTS Cellular Imaging Assay Using Cellomics™ ArrayScan VTI Platform
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Chapter title
ATM Kinase Inhibitors: HTS Cellular Imaging Assay Using Cellomics™ ArrayScan VTI Platform
Chapter number 5
Book title
ATM Kinase
Published in
Methods in molecular biology, January 2017
DOI 10.1007/978-1-4939-6955-5_5
Pubmed ID
Book ISBNs
978-1-4939-6953-1, 978-1-4939-6955-5, 978-1-4939-6953-1, 978-1-4939-6955-5
Authors

Catherine Bardelle, Joanna Boros

Editors

Sergei V. Kozlov

Abstract

Small molecule inhibitors of the ATM pathway could represent a promising opportunity for cancer therapy, working either by enhancing the clinical efficacy of radiotherapy and existing chemotherapies or by synthetic lethality-based mechanisms. In this chapter, we describe a high-throughput, high-content imaging assay monitoring levels of ATM phosphorylation at Serine 1981 following induction of DNA damage by ionizing radiation.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 5 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 2 40%
Student > Postgraduate 1 20%
Student > Ph. D. Student 1 20%
Unknown 1 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 60%
Chemistry 1 20%
Unknown 1 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 May 2017.
All research outputs
#15,459,013
of 22,971,207 outputs
Outputs from Methods in molecular biology
#5,377
of 13,142 outputs
Outputs of similar age
#257,202
of 421,094 outputs
Outputs of similar age from Methods in molecular biology
#468
of 1,074 outputs
Altmetric has tracked 22,971,207 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,142 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
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We're also able to compare this research output to 1,074 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.