| Chapter title |
Activation of Macrophages in Response to Biomaterials
|
|---|---|
| Chapter number | 13 |
| Book title |
Macrophages
|
| Published in |
Results and problems in cell differentiation, April 2017
|
| DOI | 10.1007/978-3-319-54090-0_13 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-954089-4, 978-3-31-954090-0
|
| Authors |
Jamie E. Rayahin, Richard A. Gemeinhart, Rayahin, Jamie E., Gemeinhart, Richard A. |
| Editors |
Malgorzata Kloc |
| Abstract |
Macrophages are the initial biologic responders to biomaterials. These highly plastic immune sentinels control and modulate responses to materials, foreign or natural. The responses may vary from immune stimulatory to immune suppressive. Several parameters have been identified that influence macrophage response to biomaterials, specifically size, geometry, surface topography, hydrophobicity, surface chemistry, material mechanics, and protein adsorption. In this review, the influence of these parameters is supported with examples of both synthetic and naturally derived materials and illustrates that a combination of these parameters ultimately influences macrophage responses to the biomaterial. Having an understanding of these properties may lead to highly efficient design of biomaterials with desirable biologic response properties. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Unknown | 57 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 26% |
| Student > Bachelor | 6 | 10% |
| Student > Doctoral Student | 4 | 7% |
| Researcher | 4 | 7% |
| Professor | 3 | 5% |
| Other | 10 | 17% |
| Unknown | 16 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 10 | 17% |
| Biochemistry, Genetics and Molecular Biology | 6 | 10% |
| Chemistry | 6 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 7% |
| Medicine and Dentistry | 4 | 7% |
| Other | 10 | 17% |
| Unknown | 18 | 31% |