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Lysosomes

Overview of attention for book
Cover of 'Lysosomes'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 SILAC-Based Comparative Proteomic Analysis of Lysosomes from Mammalian Cells Using LC-MS/MS. - PubMed - NCBI
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    Chapter 2 Quantitative Profiling of Lysosomal Lipidome by Shotgun Lipidomics
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    Chapter 3 Analysis of N- and O-Glycosylation of Lysosomal Glycoproteins
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    Chapter 4 Analyzing Lysosome-Related Organelles by Electron Microscopy
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    Chapter 5 Microscopic Analysis of Lysosomal Membrane Permeabilization
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    Chapter 6 Quantitative Co-Localization and Pattern Analysis of Endo-Lysosomal Cargo in Subcellular Image Cytometry and Validation on Synthetic Image Sets
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    Chapter 7 Preparation of a Two-Photon Fluorescent Probe for Imaging H2O2 in Lysosomes in Living Cells and Tissues
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    Chapter 8 Lysophagy: A Method for Monitoring Lysosomal Rupture Followed by Autophagy-Dependent Recovery
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    Chapter 9 Delivery of Cargo to Lysosomes Using GNeosomes
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    Chapter 10 Lysosomal Acidification in Cultured Astrocytes Using Nanoparticles
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    Chapter 11 Analysis of Lysosomal pH by Flow Cytometry Using FITC-Dextran Loaded Cells
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    Chapter 12 Detection of Lysosomal Exocytosis in Platelets by Flow Cytometry
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    Chapter 13 Detection of Lysosomal Exocytosis by Surface Exposure of Lamp1 Luminal Epitopes
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    Chapter 14 Using the MEROPS Database for Investigation of Lysosomal Peptidases, Their Inhibitors, and Substrates
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    Chapter 15 Next-Generation Sequencing Approaches to Define the Role of the Autophagy Lysosomal Pathway in Human Disease: The Example of LysoPlex
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    Chapter 16 Gelatin Zymography Using Leupeptin for the Detection of Various Cathepsin L Forms
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    Chapter 17 Methods for Determination of α-Glycosidase, β-Glycosidase, and α-Galactosidase Activities in Dried Blood Spot Samples
  19. Altmetric Badge
    Chapter 18 Prenatal Diagnosis of Lysosomal Storage Disorders Using Chorionic Villi
  20. Altmetric Badge
    Chapter 19 Lysosomal Biology in Cancer
Attention for Chapter 19: Lysosomal Biology in Cancer
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
1 news outlet
twitter
2 X users
patent
1 patent

Citations

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5 Dimensions

Readers on

mendeley
88 Mendeley
Summary News X Patents Dimensions citations
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Chapter title
Lysosomal Biology in Cancer
Chapter number 19
Book title
Lysosomes
Published in
Methods in molecular biology, April 2017
DOI 10.1007/978-1-4939-6934-0_19
Pubmed ID
28456991
Book ISBNs
978-1-4939-6932-6, 978-1-4939-6934-0
Authors

Fennelly, Colin, Amaravadi, Ravi K., Colin Fennelly, Ravi K. Amaravadi

Editors

Karin Öllinger, Hanna Appelqvist

Abstract

Cells depend on the lysosome for sequestration and degradation of macromolecules in order to maintain metabolic homeostasis. These membrane-enclosed organelles can receive intracellular and extracellular cargo through endocytosis, phagocytosis, and autophagy. Lysosomes establish acidic environments to activate enzymes that are able to break down biomolecules engulfed through these various pathways. Recent advances in methods to study the lysosome have allowed the discovery of extended roles for the lysosome in various diseases, including cancer, making it an attractive and targetable node for therapeutic intervention. This review focuses on key aspects of lysosomal biology in the context of cancer and how these properties can be exploited for the development of new therapeutic strategies. This will provide a contextual framework for how advances in methodology could be applied in future translational research.

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X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 88 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 13%
Student > Master 11 13%
Researcher 9 10%
Student > Bachelor 6 7%
Professor > Associate Professor 6 7%
Other 14 16%
Unknown 31 35%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 26 30%
Agricultural and Biological Sciences 10 11%
Pharmacology, Toxicology and Pharmaceutical Science 6 7%
Medicine and Dentistry 2 2%
Immunology and Microbiology 2 2%
Other 8 9%
Unknown 34 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 July 2021.
All research outputs
#2,358,804
of 22,968,808 outputs
Outputs from Methods in molecular biology
#419
of 13,142 outputs
Outputs of similar age
#46,256
of 310,341 outputs
Outputs of similar age from Methods in molecular biology
#5
of 282 outputs
Altmetric has tracked 22,968,808 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,142 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 310,341 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 282 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.

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