Chapter title |
Prix Fixe: Efferocytosis as a Four-Course Meal.
|
---|---|
Chapter number | 467 |
Book title |
Apoptotic and Non-apoptotic Cell Death
|
Published in |
Current topics in microbiology and immunology, August 2015
|
DOI | 10.1007/82_2015_467 |
Pubmed ID | |
Book ISBNs |
978-3-31-923912-5, 978-3-31-923913-2
|
Authors |
Martinez, Jennifer, Jennifer Martinez |
Editors |
Shigekazu Nagata, Hiroyasu Nakano |
Abstract |
During development, stress, infection, or normal homeostasis, billions of cells die on a daily basis, and the responsibility of clearing these cellular corpses lies with the phagocytes of innate immune system. This process, termed efferocytosis , is critical for the prevention of inflammation and autoimmunity , as well as modulation of the adaptive immune response. Defective clearance of dead cells is characteristic of many human autoimmune or autoinflammatory disorders, such as systemic lupus erythematosus (SLE), atherosclerosis, and diabetes. The mechanisms that phagocytes employ to sense, engulf, and process dead cells for an appropriate immune response have been an area of great interest. However, insight into novel mechanisms of programmed cell death , such as necroptosis, has shed light on the fact that while the diner (or phagocyte) is important, the meal itself (the type of dead cell) can play a crucial role in shaping the pursuant immune response. |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Student > Ph. D. Student | 11 | 26% |
Student > Master | 8 | 19% |
Student > Bachelor | 5 | 12% |
Student > Doctoral Student | 4 | 9% |
Researcher | 3 | 7% |
Other | 5 | 12% |
Unknown | 7 | 16% |
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Biochemistry, Genetics and Molecular Biology | 5 | 12% |
Agricultural and Biological Sciences | 4 | 9% |
Psychology | 3 | 7% |
Other | 7 | 16% |
Unknown | 9 | 21% |