Chapter title |
Cellular FLICE-Inhibitory Protein Regulates Tissue Homeostasis
|
---|---|
Chapter number | 448 |
Book title |
Apoptotic and Non-apoptotic Cell Death
|
Published in |
Current topics in microbiology and immunology, July 2015
|
DOI | 10.1007/82_2015_448 |
Pubmed ID | |
Book ISBNs |
978-3-31-923912-5, 978-3-31-923913-2
|
Authors |
Hiroyasu Nakano, Xuehua Piao, Ryodai Shindo, Sachiko Komazawa-Sakon |
Editors |
Shigekazu Nagata, Hiroyasu Nakano |
Abstract |
Cellular FLICE-inhibitory protein (cFLIP) is structurally related to caspase-8, but lacks its protease activity. Cflip gene encodes several splicing variants including short form (cFLIPs) and long form (cFLIPL). cFLIPL is composed of two death effector domains at the N terminus and a C-terminal caspase-like domain, and cFLIPs lacks the caspase-like domain. Our studies reveal that cFLIP plays a central role in NF-κB-dependent survival signals that control apoptosis and programmed necrosis. Germline deletion of Cflip results in embryonic lethality due to enhanced apoptosis and programmed necrosis; however, the combined deletion of the death-signaling regulators, Fadd and Ripk3, prevents embryonic lethality in Cflip-deficient mice. Moreover, tissue-specific deletion of Cflip reveals cFLIP as a crucial regulator that maintains tissue homeostasis of immune cells, hepatocytes, intestinal epithelial cells, and epidermal cells by preventing apoptosis and programmed necrosis. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 5 | 26% |
Student > Bachelor | 3 | 16% |
Student > Ph. D. Student | 3 | 16% |
Researcher | 2 | 11% |
Other | 1 | 5% |
Other | 1 | 5% |
Unknown | 4 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 6 | 32% |
Medicine and Dentistry | 5 | 26% |
Agricultural and Biological Sciences | 3 | 16% |
Immunology and Microbiology | 2 | 11% |
Unknown | 3 | 16% |