| Chapter title |
The Canonical Inflammasome: A Macromolecular Complex Driving Inflammation
|
|---|---|
| Chapter number | 2 |
| Book title |
Macromolecular Protein Complexes
|
| Published in |
Sub cellular biochemistry, March 2017
|
| DOI | 10.1007/978-3-319-46503-6_2 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-946501-2, 978-3-31-946503-6
|
| Authors |
Tom P. Monie, Monie, Tom P. |
| Editors |
J. Robin Harris, Jon Marles-Wright |
| Abstract |
The inflammasome is a multi-molecular platform crucial to the induction of an inflammatory response to cellular danger. Recognition in the cytoplasm of endogenously and exogenously derived ligands initiates conformational change in sensor proteins, such as NLRP3, that permits the subsequent rapid recruitment of adaptor proteins, like ASC, and the resulting assembly of a large-scale inflammatory signalling platform. The assembly process is driven by sensor-sensor interactions as well as sensor-adaptor and adaptor-adaptor interactions. The resulting complex, which can reach diameters of around 1 micron, has a variable composition and stoichiometry. The inflammasome complex functions as a platform for the proximity induced activation of effector caspases, such as caspase-1 and caspase-8. This ultimately leads to the processing of the inflammatory cytokines pro-IL1β and pro-IL18 into their active forms, along with the cleavage of Gasdermin D, a key activator of cell death via pyroptosis. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 24 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 4 | 17% |
| Researcher | 4 | 17% |
| Professor > Associate Professor | 3 | 13% |
| Student > Master | 3 | 13% |
| Student > Doctoral Student | 2 | 8% |
| Other | 4 | 17% |
| Unknown | 4 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 33% |
| Medicine and Dentistry | 3 | 13% |
| Immunology and Microbiology | 3 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 8% |
| Unspecified | 1 | 4% |
| Other | 3 | 13% |
| Unknown | 4 | 17% |