| Chapter title |
Prophase I: Preparing Chromosomes for Segregation in the Developing Oocyte
|
|---|---|
| Chapter number | 5 |
| Book title |
Signaling-Mediated Control of Cell Division
|
| Published in |
Results and problems in cell differentiation, March 2017
|
| DOI | 10.1007/978-3-319-44820-6_5 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-944819-0, 978-3-31-944820-6
|
| Authors |
Reichman, Rachel, Alleva, Benjamin, Smolikove, Sarit, Rachel Reichman, Benjamin Alleva, Sarit Smolikove |
| Abstract |
Formation of an oocyte involves a specialized cell division termed meiosis. In meiotic prophase I (the initial stage of meiosis), chromosomes undergo elaborate events to ensure the proper segregation of their chromosomes into gametes. These events include processes leading to the formation of a crossover that, along with sister chromatid cohesion, forms the physical link between homologous chromosomes. Crossovers are formed as an outcome of recombination. This process initiates with programmed double-strand breaks that are repaired through the use of homologous chromosomes as a repair template. The accurate repair to form crossovers takes place in the context of the synaptonemal complex, a protein complex that links homologous chromosomes in meiotic prophase I. To allow proper execution of meiotic prophase I events, signaling processes connect different steps in recombination and synapsis. The events occurring in meiotic prophase I are a prerequisite for proper chromosome segregation in the meiotic divisions. When these processes go awry, chromosomes missegregate. These meiotic errors are thought to increase with aging and may contribute to the increase in aneuploidy observed in advanced maternal age female oocytes. |
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Demographic breakdown
| Type | Count | As % |
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Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 21 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
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| Researcher | 3 | 14% |
| Student > Bachelor | 3 | 14% |
| Librarian | 1 | 5% |
| Lecturer | 1 | 5% |
| Other | 4 | 19% |
| Unknown | 4 | 19% |
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|---|---|---|
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| Other | 0 | 0% |
| Unknown | 6 | 29% |