Chapter title |
Translational Control of Germ Cell Decisions
|
---|---|
Chapter number | 6 |
Book title |
Signaling-Mediated Control of Cell Division
|
Published in |
Results and problems in cell differentiation, January 2017
|
DOI | 10.1007/978-3-319-44820-6_6 |
Pubmed ID | |
Book ISBNs |
978-3-31-944819-0, 978-3-31-944820-6
|
Authors |
Kumari Pushpa, Ganga Anil Kumar, Kuppuswamy Subramaniam, Pushpa, Kumari, Kumar, Ganga Anil, Subramaniam, Kuppuswamy |
Abstract |
Germline poses unique challenges to gene expression control at the transcriptional level. While the embryonic germline maintains a global hold on new mRNA transcription, the female adult germline produces transcripts that are not translated into proteins until embryogenesis of subsequent generation. As a consequence, translational control plays a central role in governing various germ cell decisions including the formation of primordial germ cells, self-renewal/differentiation decisions in the adult germline, onset of gametogenesis and oocyte maturation. Mechanistically, several common themes such as asymmetric localization of mRNAs, conserved RNA-binding proteins that control translation by 3' UTR binding, translational activation by the cytoplasmic elongation of the polyA tail and the assembly of mRNA-protein complexes called mRNPs have emerged from the studies on Caenorhabditis elegans, Xenopus and Drosophila. How mRNPs assemble, what influences their dynamics, and how a particular 3' UTR-binding protein turns on the translation of certain mRNAs while turning off other mRNAs at the same time and space are key challenges for future work. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 26% |
Student > Bachelor | 2 | 11% |
Student > Doctoral Student | 2 | 11% |
Lecturer | 1 | 5% |
Other | 1 | 5% |
Other | 4 | 21% |
Unknown | 4 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 11 | 58% |
Agricultural and Biological Sciences | 2 | 11% |
Business, Management and Accounting | 1 | 5% |
Medicine and Dentistry | 1 | 5% |
Unknown | 4 | 21% |