Chapter title |
Role of P2Y12 Receptor in Thrombosis
|
---|---|
Chapter number | 123 |
Book title |
Thrombosis and Embolism: from Research to Clinical Practice
|
Published in |
Advances in experimental medicine and biology, September 2016
|
DOI | 10.1007/5584_2016_123 |
Pubmed ID | |
Book ISBNs |
978-3-31-922107-6, 978-3-31-922108-3
|
Authors |
Yaqi Zhang, Si Zhang, Zhongren Ding |
Editors |
Md. Shahidul Islam |
Abstract |
P2Y12 receptor is a 342 amino acid Gi-coupled receptor predominantly expressed on platelets. P2Y12 receptor is physiologically activated by ADP and inhibits adenyl cyclase (AC) to decrease cyclic AMP (cAMP) level, resulting in platelet aggregation. It also activates PI3 kinase (PI3K) pathway leading to fibrinogen receptor activation, and may protect platelets from apoptosis. Abnormalities of P2Y12 receptor include congenital deficiencies or high activity in diseases like diabetes mellitus (DM) and chronic kidney disease (CKD), exposing such patients to a prothrombotic condition. A series of clinical antiplatelet drugs, such as clopidogrel and ticagrelor, are designed as indirect or direct antagonists of P2Y12 receptor to reduce incidence of thrombosis mainly for patients of acute coronary syndrome (ACS) who are at high risk of thrombotic events. Studies on novel dual-/multi-target antiplatelet agents consider P2Y12 receptor as a promising part in combined targets. However, the clinical practical phenomena, such as "clopidogrel resistance" due to gene variations of cytochrome P450 or P2Y12 receptor constitutive activation, call for better antiplatelet agents. Researches also showed inverse agonist of P2Y12 receptor could play a better role over neutral antagonists. Personalized antiplatelet therapy is the most ideal destination for antiplatelet therapy in ACS patients with or without other underlying diseases like DM or CKD, however, there is still a long way to go. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 36 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 6 | 17% |
Student > Bachelor | 5 | 14% |
Student > Ph. D. Student | 4 | 11% |
Student > Postgraduate | 3 | 8% |
Researcher | 3 | 8% |
Other | 3 | 8% |
Unknown | 12 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 28% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 14% |
Biochemistry, Genetics and Molecular Biology | 3 | 8% |
Agricultural and Biological Sciences | 2 | 6% |
Immunology and Microbiology | 2 | 6% |
Other | 1 | 3% |
Unknown | 13 | 36% |