Chapter title |
Thrombolytic Therapy by Tissue Plasminogen Activator for Pulmonary Embolism
|
---|---|
Chapter number | 106 |
Book title |
Thrombosis and Embolism: from Research to Clinical Practice
|
Published in |
Advances in experimental medicine and biology, September 2016
|
DOI | 10.1007/5584_2016_106 |
Pubmed ID | |
Book ISBNs |
978-3-31-922107-6, 978-3-31-922108-3
|
Authors |
Md. Shahidul Islam M.D., Ph.D., Md. Shahidul Islam |
Editors |
Md. Shahidul Islam |
Abstract |
Clinicians need to make decisions about the use of thrombolytic (fibrinolytic) therapy for pulmonary embolism (PE) after carefully considering the risks of major complications from bleeding, and the benefits of treatment, for each individual patient. They should probably not use systemic thrombolysis for PE patients with normal blood pressure. Treatment by human recombinant tissue plasminogen activator (rt-PA), alteplase, saves the lives of high-risk PE patients, that is, those with hypotension or in shock. Even in the absence of strong evidence, clinicians need to choose the most appropriate regimen for administering alteplase for individual patients, based on assessment of the urgency of the situation, risks for major complications from bleeding, and patient's body weight. In addition, invasive strategies should be considered when absolute contraindications for thrombolytic therapy exist, serious complications arise, or thrombolytic therapy fails. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 4 | 16% |
Student > Master | 4 | 16% |
Student > Bachelor | 3 | 12% |
Researcher | 3 | 12% |
Student > Doctoral Student | 3 | 12% |
Other | 4 | 16% |
Unknown | 4 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 28% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 8% |
Social Sciences | 2 | 8% |
Nursing and Health Professions | 1 | 4% |
Computer Science | 1 | 4% |
Other | 3 | 12% |
Unknown | 9 | 36% |