Chapter title |
Quasispecies: From Theory to Experimental Systems
|
---|---|
Chapter number | 459 |
Book title |
Quasispecies: From Theory to Experimental Systems
|
Published in |
Current topics in microbiology and immunology, August 2015
|
DOI | 10.1007/82_2015_459 |
Pubmed ID | |
Book ISBNs |
978-3-31-923897-5, 978-3-31-923898-2
|
Authors |
Perales, Celia, Domingo, Esteban, Celia Perales, Esteban Domingo |
Abstract |
The concept of error threshold derived from quasispecies theory is at the basis of lethal mutagenesis, a new antiviral strategy based on the increase of virus mutation rate above an extinction threshold. Research on this strategy is justified by several inhibitor-escape routes that viruses utilize to ensure their survival. Successive steps in the transition from an organized viral quasispecies into loss of biologically meaningful genomic sequences are dissected. The possible connections between theoretical models and experimental observations on lethal mutagenesis are reviewed. The possibility of using combination of virus-specific mutagenic nucleotide analogues and broad-spectrum, non-mutagenic inhibitors is evaluated. We emphasize the power that quasispecies theory has had to stimulate exploration of new means to combat pathogenic viruses. |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 32 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 19% |
Student > Bachelor | 5 | 16% |
Student > Ph. D. Student | 5 | 16% |
Student > Doctoral Student | 2 | 6% |
Professor | 2 | 6% |
Other | 3 | 9% |
Unknown | 9 | 28% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 4 | 13% |
Medicine and Dentistry | 3 | 9% |
Immunology and Microbiology | 1 | 3% |
Nursing and Health Professions | 1 | 3% |
Other | 0 | 0% |
Unknown | 12 | 38% |