Chapter title |
Identification and Clinical Translation of Biomarker Signatures: Statistical Considerations.
|
---|---|
Chapter number | 6 |
Book title |
Multiplex Biomarker Techniques
|
Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-6730-8_6 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6729-2, 978-1-4939-6730-8
|
Authors |
Emanuel Schwarz |
Editors |
Paul C. Guest |
Abstract |
Powerful machine learning tools exist to extract biological patterns for diagnosis or prediction from high-dimensional datasets. Simultaneous advances in high-throughput profiling technologies have led to a rapid acceleration of biomarker discovery investigations across all areas of medicine. However, the translation of biomarker signatures into clinically useful tools has thus far been difficult. In this chapter, several important considerations are discussed that influence such translation in the context of classifier design. These include aspects of variable selection that go beyond classification accuracy, as well as effects of variability on assay stability and sample size. The consideration of such factors may lead to an adaptation of biomarker discovery approaches, aimed at an optimal balance of performance and clinical translatability. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 3 | 20% |
Other | 2 | 13% |
Student > Ph. D. Student | 2 | 13% |
Researcher | 2 | 13% |
Professor | 1 | 7% |
Other | 2 | 13% |
Unknown | 3 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 20% |
Nursing and Health Professions | 2 | 13% |
Psychology | 2 | 13% |
Neuroscience | 2 | 13% |
Sports and Recreations | 1 | 7% |
Other | 1 | 7% |
Unknown | 4 | 27% |