| Chapter title |
Blood Bio-Sampling Procedures for Multiplex Biomarkers Studies.
|
|---|---|
| Chapter number | 12 |
| Book title |
Multiplex Biomarker Techniques
|
| Published in |
Methods in molecular biology, January 2017
|
| DOI | 10.1007/978-1-4939-6730-8_12 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-6729-2, 978-1-4939-6730-8
|
| Authors |
Paul C. Guest, Hassan Rahmoune |
| Editors |
Paul C. Guest |
| Abstract |
A major challenge in single or panel of biomarker discovery and validation is the inherent biological complexity underlying disease heterogeneity and inconsistent responses to treatment. Moreover, the lack of standardization in the sampling, processing, and storage of biological fluids such as plasma and serum disrupts the discovery and validation of blood-based biomarker tests in preclinical and clinical settings. This chapter presents a reproducible sample collection and handling procedure that aims to enhance analyte stability and ensure compatibility with the corresponding multiplex biomarker profiling platforms. The importance of defining bio-sample acquisition and processing, study design, and profiling platform guidelines for blood-based biomarker measurements is paramount for the success of personalized healthcare strategy and development of companion diagnostics. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 7 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 2 | 29% |
| Student > Bachelor | 1 | 14% |
| Researcher | 1 | 14% |
| Student > Master | 1 | 14% |
| Unknown | 2 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 2 | 29% |
| Psychology | 1 | 14% |
| Medicine and Dentistry | 1 | 14% |
| Engineering | 1 | 14% |
| Unknown | 2 | 29% |