| Chapter title |
Dosing Psychedelics and MDMA
|
|---|---|
| Chapter number | 270 |
| Book title |
Disruptive Psychopharmacology
|
| Published in |
Current topics in behavioral neurosciences, January 2021
|
| DOI | 10.1007/7854_2021_270 |
| Pubmed ID | |
| Book ISBNs |
978-3-03-112183-8, 978-3-03-112184-5
|
| Authors |
Liechti, Matthias E., Holze, Friederike, Liechti, Matthias E |
| Abstract |
Classic psychedelics, including psilocybin, lysergic acid diethylamide (LSD), dimethyltryptamine, and mescaline, and entactogens/empathogens, especially 3,4-methylenedioxymethamphetamine, have received renewed attention in psychiatric research and may be developed into medications for such indications as anxiety, depression, cluster headache, and posttraumatic stress disorder, among others. However, identifying proper doses is crucial. Controlled study data on dosing using well-characterized pharmaceutical formulations of the substances are scarce. The dose equivalence of different substances, dose-response effects, and subjective effects of different doses are of great interest and practically important for their clinical use in psychotherapy. Furthermore, the so-called microdosing of psychedelics has recently gained popularity, and the first placebo-controlled studies of LSD have been published. This chapter discusses different aspects of psychedelic dosing, including pharmaceutical aspects, definitions and characteristics of different doses, including microdoses, aspects of personalized dosing, and non-pharmacological factors, that can influence the response to psychedelics. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 60 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 7 | 12% |
| Student > Doctoral Student | 5 | 8% |
| Student > Ph. D. Student | 4 | 7% |
| Researcher | 4 | 7% |
| Student > Master | 3 | 5% |
| Other | 4 | 7% |
| Unknown | 33 | 55% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 9 | 15% |
| Medicine and Dentistry | 9 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Neuroscience | 2 | 3% |
| Nursing and Health Professions | 1 | 2% |
| Other | 4 | 7% |
| Unknown | 33 | 55% |