Chapter title |
Pseudotyped Viruses for Orthohantavirus.
|
---|---|
Chapter number | 12 |
Book title |
Pseudotyped Viruses
|
Published in |
Advances in experimental medicine and biology, January 2023
|
DOI | 10.1007/978-981-99-0113-5_12 |
Pubmed ID | |
Book ISBNs |
978-9-81-990112-8, 978-9-81-990113-5
|
Authors |
Ning, Tingting, Huang, Weijin, Min, Li, Yang, Yi, Liu, Si, Xu, Junxuan, Zhang, Nan, Xie, Si-An, Zhu, Shengtao, Wang, Youchun |
Abstract |
Orthohantaviruses, members of the Orthohantavirus genus of Hantaviridae family of the Bunyavirales order, are enveloped, negative-sense, single-stranded, tripartite RNA viruses. They are emerging zoonotic pathogens carried by small mammals including rodents, moles, shrews, and bats and are the etiologic agents of hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS) among humans. With the characteristics of low biological risk but strong operability, a variety of pseudotyped viruses have been constructed as alternatives to authentic orthohantaviruses to help delineate the roles of host factors in viral entry and other virus-host interactions, to assist in deciphering mechanisms of immune response and correlates of protection, to enhance our understanding of viral antigenic property, to characterize viral entry inhibitors, and to be developed as vaccines. In this chapter, we will discuss the general property of orthohantavirus, construction of pseudotyped orthohantaviruses based on different packaging systems, and their current applications. |
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Student > Master | 1 | 17% |
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Veterinary Science and Veterinary Medicine | 1 | 17% |
Agricultural and Biological Sciences | 1 | 17% |
Unknown | 4 | 67% |