| Chapter title |
Obesity Biomarkers, Metabolism and Risk of Cancer: An Epidemiological Perspective
|
|---|---|
| Chapter number | 11 |
| Book title |
Obesity and Cancer
|
| Published in |
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, December 2016
|
| DOI | 10.1007/978-3-319-42542-9_11 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-942540-5, 978-3-31-942542-9, 978-3-31-942540-5, 978-3-31-942542-9
|
| Authors |
Katharina Nimptsch, Tobias Pischon, Nimptsch, Katharina, Pischon, Tobias |
| Editors |
Tobias Pischon, Katharina Nimptsch |
| Abstract |
Obesity is associated with metabolic alterations that may pose a biological link between body fatness and risk of cancer. Elucidating the role of obesity-related biomarkers in cancer development is essential for developing targeted strategies aiming at obesity-associated cancer prevention. Molecular epidemiological studies of the past decades have provided evidence that major hormonal pathways linking obesity and cancer risk include the insulin and insulin-like growth factor-1 (IGF-1) axis, sex-steroid hormones, adipokines and chronic low-grade inflammation. These pathways are interrelated with each other, and their importance varies by obesity-related cancer type. The insulin/IGF-1 axis has been implicated to play an important mediating role in the association between obesity and risk of pancreatic, colorectal and prostate cancer. Endogenous sex-steroid hormone concentrations, in particular obesity-associated pre-diagnostic elevations of estrogens and androgens, play an important role in postmenopausal breast cancer and endometrial cancer development. The adipokines adiponectin and leptin and adipocyte-mediated chronic low-grade inflammation represented by the acute-phase C-reactive protein may explain a substantial part of the association between obesity and risk of colorectal cancer. There is less evidence on whether these hormonal pathways play a mediating role in other obesity-associated types of cancer. In this chapter, the molecular epidemiologic evidence from prospective studies relating circulating obesity-related biomarkers to cancer risk is summarized, taking into account available evidence from Mendelian Randomization investigations aiming at improving causal inference. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 79 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 14% |
| Student > Master | 11 | 14% |
| Student > Ph. D. Student | 10 | 13% |
| Student > Bachelor | 7 | 9% |
| Other | 6 | 8% |
| Other | 8 | 10% |
| Unknown | 26 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 24 | 30% |
| Biochemistry, Genetics and Molecular Biology | 7 | 9% |
| Agricultural and Biological Sciences | 5 | 6% |
| Sports and Recreations | 3 | 4% |
| Nursing and Health Professions | 2 | 3% |
| Other | 7 | 9% |
| Unknown | 31 | 39% |