| Chapter title |
Assembly, Engineering and Applications of Virus-Based Protein Nanoparticles.
|
|---|---|
| Chapter number | 5 |
| Book title |
Protein-based Engineered Nanostructures
|
| Published in |
Advances in experimental medicine and biology, September 2016
|
| DOI | 10.1007/978-3-319-39196-0_5 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-939194-6, 978-3-31-939196-0
|
| Authors |
Mauricio G. Mateu, Mateu, Mauricio G. |
| Editors |
Aitziber L. Cortajarena, Tijana Z. Grove |
| Abstract |
Viruses and their protein capsids can be regarded as biologically evolved nanomachines able to perform multiple, complex biological functions through coordinated mechano-chemical actions during the infectious cycle. The advent of nanoscience and nanotechnology has opened up, in the last 10 years or so, a vast number of novel possibilities to exploit engineered viral capsids as protein-based nanoparticles for multiple biomedical, biotechnological or nanotechnological applications. This chapter attempts to provide a broad, updated overview on the self-assembly and engineering of virus capsids, and on applications of virus-based nanoparticles. Different sections provide outlines on: (i) the structure, functions and properties of virus capsids; (ii) general approaches for obtaining assembled virus particles; (iii) basic principles and events related to virus capsid self-assembly; (iv) genetic and chemical strategies for engineering virus particles; (v) some applications of engineered virus particles being developed; and (vi) some examples on the engineering of virus particles to modify their physical properties, in order to improve their suitability for different uses. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 33 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 15% |
| Student > Ph. D. Student | 4 | 12% |
| Student > Bachelor | 3 | 9% |
| Other | 3 | 9% |
| Student > Master | 2 | 6% |
| Other | 5 | 15% |
| Unknown | 11 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 24% |
| Engineering | 4 | 12% |
| Agricultural and Biological Sciences | 3 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
| Materials Science | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 14 | 42% |