Chapter title |
Anti-inflammatory Nutraceuticals and Chronic Diseases
|
---|---|
Chapter number | 9 |
Book title |
Anti-inflammatory Nutraceuticals and Chronic Diseases
|
Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/978-3-319-41334-1_9 |
Pubmed ID | |
Book ISBNs |
978-3-31-941332-7, 978-3-31-941334-1
|
Authors |
Surh, Young-Joon, Na, Hye-Kyung, Young-Joon Surh, Hye-Kyung Na |
Abstract |
Piceatannol (3,3',4,5'-tetrahydroxy-trans-stilbene; PIC) is a naturally occurring stilbene present in diverse plant sources. PIC is a hydroxylated analog of resveratrol and produced from resveratrol by microsomal cytochrome P450 1A11/2 and 1B1 activities. Like resveratrol, PIC has a broad spectrum of health beneficial effects, many of which are attributable to its antioxidative and anti-inflammatory activities. PIC exerts anticarcinogenic effects by targeting specific proteins involved in regulating cancer cell proliferation, survival/death, invasion, metastasis, angiogenesis, etc. in tumor microenvironment. PIC also has other health promoting and disease preventing functions, such as anti-obese, antidiabetic, neuroptotective, cardioprotective, anti-allergic, anti-aging properties. This review outlines the principal biological activities of PIC and underlying mechanisms with special focus on intracellular signaling molecules/pathways involved. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 46 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 17% |
Student > Master | 7 | 15% |
Student > Bachelor | 5 | 11% |
Student > Doctoral Student | 5 | 11% |
Researcher | 3 | 7% |
Other | 7 | 15% |
Unknown | 11 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 12 | 26% |
Medicine and Dentistry | 7 | 15% |
Biochemistry, Genetics and Molecular Biology | 4 | 9% |
Agricultural and Biological Sciences | 3 | 7% |
Unspecified | 1 | 2% |
Other | 3 | 7% |
Unknown | 16 | 35% |