| Chapter title |
Regulation of IL-4 Expression in Immunity and Diseases.
|
|---|---|
| Chapter number | 3 |
| Book title |
Regulation of Cytokine Gene Expression in Immunity and Diseases
|
| Published in |
Advances in experimental medicine and biology, October 2016
|
| DOI | 10.1007/978-94-024-0921-5_3 |
| Pubmed ID | |
| Book ISBNs |
978-9-40-240919-2, 978-9-40-240921-5
|
| Authors |
I-Cheng Ho, Shi-Chuen Miaw, Ho, I-Cheng, Miaw, Shi-Chuen |
| Editors |
Xiaojing Ma |
| Abstract |
IL-4 was first identified as a T cell-derived growth factor for B cells. Studies over the past several decades have markedly expanded our understanding of its cellular sources and function. In addition to T cells, IL-4 is produced by innate lymphocytes, such as NTK cells, and myeloid cells, such as basophils and mast cells. It is a signature cytokine of type 2 immune response but also has a nonimmune function. Its expression is tightly regulated at several levels, including signaling pathways, transcription factors, epigenetic modifications, microRNA, and long noncoding RNA. This chapter will review in detail the molecular mechanism regulating the cell type-specific expression of IL-4 in physiological and pathological type 2 immune responses. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 61 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 10 | 16% |
| Student > Ph. D. Student | 9 | 15% |
| Researcher | 7 | 11% |
| Student > Doctoral Student | 4 | 7% |
| Student > Master | 3 | 5% |
| Other | 1 | 2% |
| Unknown | 27 | 44% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 15% |
| Biochemistry, Genetics and Molecular Biology | 8 | 13% |
| Immunology and Microbiology | 7 | 11% |
| Agricultural and Biological Sciences | 3 | 5% |
| Neuroscience | 3 | 5% |
| Other | 4 | 7% |
| Unknown | 27 | 44% |