Chapter title |
Regulation of IL-6 in Immunity and Diseases.
|
---|---|
Chapter number | 4 |
Book title |
Regulation of Cytokine Gene Expression in Immunity and Diseases
|
Published in |
Advances in experimental medicine and biology, October 2016
|
DOI | 10.1007/978-94-024-0921-5_4 |
Pubmed ID | |
Book ISBNs |
978-9-40-240919-2, 978-9-40-240921-5
|
Authors |
Toshio Tanaka, Masashi Narazaki, Kazuya Masuda, Tadamitsu Kishimoto, Tanaka, Toshio, Narazaki, Masashi, Masuda, Kazuya, Kishimoto, Tadamitsu |
Editors |
Xiaojing Ma |
Abstract |
Interleukin-6 (IL-6) is a prototypical cytokine with functional pleiotropy and plays an important role in host defense. When infections or tissue injuries occur, IL-6 is promptly produced by monocytes and macrophages and contributes to removal of infectious agents and restoration of damaged tissues through activation of immune, hematological, and acute-phase responses. Once stress is removed from the host, IL-6 synthesis ends, but uncontrolled excessive or persistent IL-6 production plays a pathological role in the development of various inflammatory diseases and cancers, indicating that IL-6 is a double-edged sword for the host. Thus, the proper IL-6 expression is very important for host defense and is strictly controlled by chromatin structure, transcriptional regulation, and posttranscriptional modification. Differentiation status of cells, various transcription factors, RNA-binding proteins, and microRNAs are involved in this process. Since it is assumed that dysregulation of any of these regulatory molecules may cause abnormal IL-6 expression in a particular disease, further elucidation of the factors and processes involved in IL-6 expression can be expected to facilitate to clarification of pathogenesis and to identification of novel target molecule(s) for specific diseases. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 121 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 17 | 14% |
Student > Bachelor | 16 | 13% |
Student > Master | 10 | 8% |
Student > Doctoral Student | 7 | 6% |
Researcher | 6 | 5% |
Other | 13 | 11% |
Unknown | 52 | 43% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 20 | 17% |
Biochemistry, Genetics and Molecular Biology | 16 | 13% |
Immunology and Microbiology | 12 | 10% |
Agricultural and Biological Sciences | 6 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
Other | 8 | 7% |
Unknown | 55 | 45% |