| Chapter title |
Regulation and Immune Function of IL-27.
|
|---|---|
| Chapter number | 9 |
| Book title |
Regulation of Cytokine Gene Expression in Immunity and Diseases
|
| Published in |
Advances in experimental medicine and biology, October 2016
|
| DOI | 10.1007/978-94-024-0921-5_9 |
| Pubmed ID | |
| Book ISBNs |
978-9-40-240919-2, 978-9-40-240921-5
|
| Authors |
Qinghong Wang, Jianguo Liu |
| Editors |
Xiaojing Ma |
| Abstract |
IL-27 is a pleiotropic cytokine that has diverse immune regulatory activities under both physiological and pathological conditions. IL-27 enhances the functions of Th1 and CD8(+) T cells, promotes the development of Tfh and Tr1, and suppresses the functions of Th2, Treg, Th9, and Th17 cells. IL-27 is also involved in regulation of immune responses of B cells, NK, DCs, and macrophages. IL-27 production is strictly regulated at both transcriptional and posttranscriptional levels. Given its broad effects on immune regulation, IL-27 has been implicated in the pathogeneses of autoimmune and infectious diseases as well as cancers. In this chapter, the biological characters of IL-27 have been reviewed, including the molecular mechanisms of IL-27 production and the underlying cellular signaling pathway. The regulatory effects of IL-27 on immune responses in autoimmune disease, infectious disease, and cancer are also discussed. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 27 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 4 | 15% |
| Student > Ph. D. Student | 4 | 15% |
| Student > Master | 4 | 15% |
| Professor | 1 | 4% |
| Student > Doctoral Student | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 12 | 44% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 6 | 22% |
| Immunology and Microbiology | 3 | 11% |
| Veterinary Science and Veterinary Medicine | 1 | 4% |
| Mathematics | 1 | 4% |
| Arts and Humanities | 1 | 4% |
| Other | 2 | 7% |
| Unknown | 13 | 48% |