| Chapter title |
Cough and Arabinogalactan Polysaccharide from the Bark of Terminalia Arjuna.
|
|---|---|
| Chapter number | 30 |
| Book title |
Pulmonary Infection and Inflammation
|
| Published in |
Advances in experimental medicine and biology, June 2016
|
| DOI | 10.1007/5584_2016_30 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-944484-0, 978-3-31-944485-7
|
| Authors |
V. Sivová, K. Bera, B. Ray, S. Nosáľ, G. Nosáľová |
| Editors |
Mieczyslaw Pokorski |
| Abstract |
In this work we investigated the antitussive activity of the medicinal tree Terminalia arjuna. We used the stem bark for extraction and preparation of water extracted isolate and its two fractions: acetone-soluble (TA-S) and acetone precipitated (TA-P) fraction. The presence of a pectic arabinogalactan was confirmed in TA-P fraction by chromatographic and spectroscopic analysis. The antitussive activity of samples was assessed after oral administration in a dose of 50 mg.kg(-1) in healthy guinea pigs, in which cough was elicited by inhalation of citric acid (0.3 mol/L) in body plethysmograph. The water extracted isolate showed a significant ability to decrease the number of cough efforts by 64.2 %; the antitussive activity on par with that of codeine phosphate. The TA-P fraction showed the antitussive activity of 54.8 %. In contrast, TA-S fraction had only a mild antitussive activity. No changes in in vivo airway resistance were noted. We conclude that arabinogalactan is an essential component of Terminalia arjuna that underlies its antitussive action. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 15 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 3 | 20% |
| Professor | 3 | 20% |
| Unspecified | 1 | 7% |
| Researcher | 1 | 7% |
| Student > Bachelor | 1 | 7% |
| Other | 0 | 0% |
| Unknown | 6 | 40% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 4 | 27% |
| Veterinary Science and Veterinary Medicine | 1 | 7% |
| Chemical Engineering | 1 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
| Unspecified | 1 | 7% |
| Other | 2 | 13% |
| Unknown | 5 | 33% |