| Chapter title |
Sry, Sox9 and mammalian sex determination.
|
|---|---|
| Chapter number | 3 |
| Book title |
Genes and Mechanisms in Vertebrate Sex Determination
|
| Published in |
EXS, January 2001
|
| DOI | 10.1007/978-3-0348-7781-7_3 |
| Pubmed ID | |
| Book ISBNs |
978-3-03-487783-1, 978-3-03-487781-7
|
| Authors |
Peter Koopman, Koopman, Peter |
| Abstract |
Sry is the Y-chromosomal gene that acts as a trigger for male development in mammalian embryos. This gene encodes a high mobility group (HMG) box transcription factor that is known to bind to specific target sequences in DNA and to cause a bend in the chromatin. DNA bending appears to be part of the mechanism by which Sry influences transcription of genes downstream in a cascade of gene regulation leading to maleness, but the factors that cooperate with, and the direct targets of, Sry remain to be identified. One gene known to be downstream from Sry in this cascade in Sox9, which encodes a transcription factor related to Sry by the HMG box. Like Sry, mutations in Sox9 disrupt male development, but unlike Sry, the role of Sox9 is not limited to mammals. This review focuses on what is known about the two genes and their likely modes of action, and draws together recent data relating to how they might interconnect with the network of gene activity implicated in testis determination in mammals. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| New Caledonia | 1 | 4% |
| Unknown | 23 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 21% |
| Researcher | 5 | 21% |
| Other | 3 | 13% |
| Student > Bachelor | 2 | 8% |
| Professor | 2 | 8% |
| Other | 3 | 13% |
| Unknown | 4 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 11 | 46% |
| Biochemistry, Genetics and Molecular Biology | 5 | 21% |
| Medicine and Dentistry | 3 | 13% |
| Environmental Science | 1 | 4% |
| Unknown | 4 | 17% |