Chapter title |
Cancer-Associated Thrombosis: Regulatory Mechanisms and Emerging Directions
|
---|---|
Chapter number | 110 |
Book title |
Thrombosis and Embolism: from Research to Clinical Practice
|
Published in |
Advances in experimental medicine and biology, September 2016
|
DOI | 10.1007/5584_2016_110 |
Pubmed ID | |
Book ISBNs |
978-3-31-922107-6, 978-3-31-922108-3
|
Authors |
Prodger, Alice, Saha, Prakash, Smith, Alberto, Evans, Colin E, Alice Prodger, Prakash Saha Ph.D., Alberto Smith Ph.D., Colin E. Evans Ph.D., Evans, Colin E., Prakash Saha, Alberto Smith, Colin E. Evans |
Editors |
Md. Shahidul Islam |
Abstract |
Venous thrombosis is a common complication in cancer patients, and some cancer chemotherapies are associated with an increased risk of venous thromboembolism. The regulatory mechanisms that control thrombus formation and subsequent resolution in patients with cancer, however, are incompletely understood, and novel treatments for cancer-associated thrombosis may arise from a better understanding of such mechanisms. In this chapter, pathways that regulate cancer-associated thrombus formation are outlined, and the effects of anti-angiogenic cancer chemotherapies on venous thrombus resolution are highlighted. Potentially pro-thrombotic effects of anti-angiogenic agents are important considerations when managing the complications of venous thrombosis in cancer patients. |
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