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The Wilms' Tumor (WT1) Gene

Overview of attention for book
Cover of 'The Wilms' Tumor (WT1) Gene'

Table of Contents

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    Book Overview
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    Chapter 1 WT1 Mutation in Childhood Cancer.
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    Chapter 2 Clinical Aspects of WT1 and the Kidney.
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    Chapter 3 The Role of WT1 in Embryonic Development and Normal Organ Homeostasis.
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    Chapter 4 Tools and Techniques for Wt1-Based Lineage Tracing.
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    Chapter 5 Biological Systems and Methods for Studying WT1 in the Epicardium.
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    Chapter 6 Isolation and Colony Formation of Murine Bone and Bone Marrow Cells.
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    Chapter 7 Isolation and Fluorescence-Activated Cell Sorting of Murine WT1-Expressing Adipocyte Precursor Cells.
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    Chapter 8 The Wilms' Tumor (WT1) Gene
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    Chapter 9 Multiphoton Microscopy for Visualizing Lipids in Tissue.
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    Chapter 10 Function and Regulation of the Wilms' Tumor Suppressor 1 (WT1) Gene in Fish.
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    Chapter 11 Immunofluorescence Staining of Wt1 on Sections of Zebrafish Embryos and Larvae.
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    Chapter 12 Fluorescence-Activated Cell Sorting (FACS) Protocol for Podocyte Isolation in Adult Zebrafish.
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    Chapter 13 In Vitro Transcription to Study WT1 Function.
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    Chapter 14 Measuring Equilibrium Binding Constants for the WT1-DNA Interaction Using a Filter Binding Assay.
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    Chapter 15 The Wilms' Tumor (WT1) Gene
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    Chapter 16 The Wilms' Tumor (WT1) Gene
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    Chapter 17 Methods to Identify and Validate WT1-RNA Interaction.
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    Chapter 18 The Wilms' Tumor (WT1) Gene
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    Chapter 19 The Wilms' Tumor (WT1) Gene
Attention for Chapter 17: Methods to Identify and Validate WT1-RNA Interaction.
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Chapter title
Methods to Identify and Validate WT1-RNA Interaction.
Chapter number 17
Book title
The Wilms' Tumor (WT1) Gene
Published in
Methods in molecular biology, January 2016
DOI 10.1007/978-1-4939-4023-3_17
Pubmed ID
27417971
Book ISBNs
978-1-4939-4021-9, 978-1-4939-4023-3
Authors

Ruthrothaselvi Bharathavikru, Tatiana Dudnakova

Editors

Nicholas Hastie

Abstract

Tumor suppressor protein, Wt1 is a transcription factor that binds to DNA sequence similar to the Early Growth Response gene, EGR1 consensus binding sequence. Biophysical and biochemical validations have shown that the zinc fingers of Wt1 are capable of binding to both DNA and RNA albeit with different binding affinities which potentially is also isoform specific. SELEX based identification of the RNA binding motifs led to the identification of motifs which could not be translated into the in vivo context. With the advent of recent technologies that allow cross-linking of RNA and protein and high throughput sequencing techniques, it is now possible to analyze the in vivo RNA binding interactome of Wt1. This chapter outlines the initial studies that were aimed at addressing the Wt1 RNA interactome and also provides a detailed overview of some of the recent techniques used.

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Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 January 2018.
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#20,340,423
of 22,886,568 outputs
Outputs from Methods in molecular biology
#9,921
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#330,764
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Outputs of similar age from Methods in molecular biology
#1,054
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So far Altmetric has tracked 13,131 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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