Chapter title |
Estrogen Receptors
|
---|---|
Chapter number | 42 |
Book title |
Estrogen Receptors
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-3127-9_42 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3126-2, 978-1-4939-3127-9
|
Authors |
Okuhira, Keiichiro, Demizu, Yosuke, Hattori, Takayuki, Ohoka, Nobumichi, Shibata, Norihito, Kurihara, Masaaki, Naito, Mikihiko, Keiichiro Okuhira, Yosuke Demizu, Takayuki Hattori, Nobumichi Ohoka, Norihito Shibata, Masaaki Kurihara, Mikihiko Naito |
Abstract |
Manipulation of protein stability using small molecules has a great potential for both basic research and clinical therapy. Based on our protein knockdown technology, we recently developed a novel small molecule SNIPER(ER) that targets the estrogen receptor alpha (ERα) for degradation via the ubiquitin-proteasome system. This chapter describes the design and synthesis of SNIPER(ER) compounds, and methods for the evaluation of their activity in cellular system. |
X Demographics
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 3 | 27% |
Professor > Associate Professor | 2 | 18% |
Student > Ph. D. Student | 1 | 9% |
Unknown | 5 | 45% |
Readers by discipline | Count | As % |
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Chemistry | 2 | 18% |
Agricultural and Biological Sciences | 2 | 18% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 9% |
Computer Science | 1 | 9% |
Unknown | 5 | 45% |