Chapter title |
Novel Approaches to Apoptosis-Inducing Therapies.
|
---|---|
Chapter number | 8 |
Book title |
Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy
|
Published in |
Advances in experimental medicine and biology, August 2016
|
DOI | 10.1007/978-3-319-39406-0_8 |
Pubmed ID | |
Book ISBNs |
978-3-31-939404-6, 978-3-31-939406-0
|
Authors |
Mike-Andrew Westhoff, Nicolas Marschall, Klaus-Michael Debatin |
Editors |
Christopher D. Gregory |
Abstract |
Induction of apoptotic programmed cell death is one of the underlying principles of most current cancer therapies. In this review, we discuss the limitations and drawbacks of this approach and identify three distinct, but overlapping strategies to avoid these difficulties and further enhance the efficacy of apoptosis-inducing therapies. We postulate that the application of multi-targeted small molecule inhibitor cocktails will reduce the risk of the cancer cell populations developing resistance towards therapy. Following from these considerations regarding population genetics and ecology, we advocate the reconsideration of therapeutic end points to maximise the benefits, in terms of quantity and quality of life, for the patients. Finally, combining both previous points, we also suggest an altered focus on the cellular and molecular targets of therapy, i.e. targeting the (cancer cells') interaction with the tumour microenvironment. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 9 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 4 | 44% |
Student > Bachelor | 2 | 22% |
Unknown | 3 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Nursing and Health Professions | 2 | 22% |
Medicine and Dentistry | 2 | 22% |
Sports and Recreations | 1 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 11% |
Unknown | 3 | 33% |