Chapter title |
The Wilms' Tumor (WT1) Gene
|
---|---|
Chapter number | 16 |
Book title |
The Wilms' Tumor (WT1) Gene
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-4023-3_16 |
Pubmed ID | |
Book ISBNs |
978-1-4939-4021-9, 978-1-4939-4023-3
|
Authors |
Bharathavikru, Ruthrothaselvi, von Kriegsheim, Alex, Ruthrothaselvi Bharathavikru, Alex von Kriegsheim |
Editors |
Nicholas Hastie |
Abstract |
Tumor-suppressor protein Wt1 has been shown to interact with specific proteins that influence its function. These protein interactions have been identified as direct individual interactions but with the potential to exist as a part of a multiprotein complex. In order to obtain the global proteome interaction map of Wt1, an unbiased label-free endogenous immunoprecipitation was performed followed by mass spectrometry to identify protein interactions that are Wt1 centric. This chapter details the different techniques that have been used to identify and characterize Wt1-interacting proteins. |
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