| Chapter title |
Imetelstat (GRN163L)--telomerase-based cancer therapy.
|
|---|---|
| Chapter number | 16 |
| Book title |
Small Molecules in Oncology
|
| Published in |
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, October 2009
|
| DOI | 10.1007/978-3-642-01222-8_16 |
| Pubmed ID | |
| Book ISBNs |
978-3-64-201221-1, 978-3-64-201222-8
|
| Authors |
Röth A, Harley CB, Baerlocher GM, Alexander Röth, Calvin B. Harley, Gabriela M. Baerlocher, Röth, Alexander, Harley, Calvin B., Baerlocher, Gabriela M. |
| Editors |
Uwe M. Martens |
| Abstract |
Telomeres and telomerase play essential roles in the regulation of the lifespan of human cells. While normal human somatic cells do not or only transiently express telomerase and therefore shorten their telomeres with each cell division, most human cancer cells typically express high levels of telomerase and show unlimited cell proliferation. High telomerase expression allows cells to proliferate and expand long-term and therefore supports tumor growth. Owing to the high expression and its role, telomerase has become an attractive diagnostic and therapeutic cancer target. Imetelstat (GRN163L) is a potent and specific telomerase inhibitor and so far the only drug of its class in clinical trials. Here, we report on the structure and the mechanism of action of imetelstat as well as about the preclinical and clinical data and future prospects using imetelstat in cancer therapy. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 67 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 16 | 23% |
| Student > Master | 13 | 19% |
| Researcher | 6 | 9% |
| Student > Postgraduate | 5 | 7% |
| Student > Ph. D. Student | 5 | 7% |
| Other | 5 | 7% |
| Unknown | 19 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 20 | 29% |
| Medicine and Dentistry | 11 | 16% |
| Agricultural and Biological Sciences | 9 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Immunology and Microbiology | 2 | 3% |
| Other | 5 | 7% |
| Unknown | 20 | 29% |