| Chapter title |
5-Azacytidine/Azacitidine.
|
|---|---|
| Chapter number | 11 |
| Book title |
Small Molecules in Oncology
|
| Published in |
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, October 2009
|
| DOI | 10.1007/978-3-642-01222-8_11 |
| Pubmed ID | |
| Book ISBNs |
978-3-64-201221-1, 978-3-64-201222-8
|
| Authors |
Antonia Müller, Mareike Florek, Müller, Antonia, Florek, Mareike |
| Editors |
Uwe M. Martens |
| Abstract |
5-Azacytidine is a pyrimidine nucleoside analog that has been discovered more than 40 years ago. Despite remarkable responses in the treatment of acute myeloid leukemias in the 1970s no earlier than 2004 has this agent been approved by the US FDA for the treatment of all subtypes of myelodysplatic syndromes (MDS). For the first time a drug was proven to alter the natural course of MDS, as demonstrated in three clinical trials conducted by the CALG B. Complete remission rates ranged between 10-17%, and more recently, a significant survival benefit for MDS patients treated with 5-Azacytidine could be established. The antineoplastic activity is due to incorporation into RNA with disruption of RNA metabolism, and inhibition of DNA methylation.Strategies of combining epigenetic manipulation with other 'new' drugs aim at increasing the efficacy of the hypomethylating agents. Particularly histone deacetylase inhibitors have been deemed useful therapeutic partners, and preliminary results are promising. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 53 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 9 | 17% |
| Student > Bachelor | 9 | 17% |
| Student > Ph. D. Student | 5 | 9% |
| Student > Doctoral Student | 3 | 6% |
| Researcher | 2 | 4% |
| Other | 4 | 8% |
| Unknown | 21 | 40% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 16 | 30% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 9% |
| Medicine and Dentistry | 4 | 8% |
| Agricultural and Biological Sciences | 3 | 6% |
| Business, Management and Accounting | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 22 | 42% |