Chapter title |
Hypoxia
|
---|---|
Chapter number | 1 |
Book title |
Hypoxia
|
Published in |
Advances in experimental medicine and biology, June 2016
|
DOI | 10.1007/978-1-4899-7678-9_1 |
Pubmed ID | |
Book ISBNs |
978-1-4899-7676-5, 978-1-4899-7678-9
|
Authors |
Herceg, Zdenko, Zdenko Herceg |
Editors |
Robert C. Roach, Peter H. Hackett, Peter D. Wagner |
Abstract |
Recent advances in epigenetics have had tremendous impact on our thinking and understanding of biological phenomena and the impact of environmental stressors on complex diseases, notably cancer. Environmental and lifestyle factors are thought to be implicated in the development of a wide range of human cancers by eliciting epigenetic changes, however, the underlying mechanisms remain poorly understood. Epigenetic mechanisms can be viewed as an interface between the genome and environmental influence, therefore aberrant epigenetic events associated with environmental stressors and factors in the cell microenvironment are likely to play an important role in the onset and progression of different human malignancies. At the cellular level, aberrant epigenetic events influence critical cellular events (such as gene expression, carcinogen detoxification, DNA repair, and cell cycle), which are further modulated by risk factor exposures and thus may define the severity/subtype of cancer. This review summarizes recent progress in our understanding of the epigenetic mechanisms through which environmental stressors and endogenous factors may promote tumor development and progression. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 3 | 15% |
Researcher | 3 | 15% |
Student > Master | 2 | 10% |
Professor | 2 | 10% |
Other | 1 | 5% |
Other | 3 | 15% |
Unknown | 6 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 6 | 30% |
Engineering | 2 | 10% |
Unspecified | 1 | 5% |
Nursing and Health Professions | 1 | 5% |
Linguistics | 1 | 5% |
Other | 2 | 10% |
Unknown | 7 | 35% |