| Chapter title |
West Nile Virus
|
|---|---|
| Chapter number | 1 |
| Book title |
West Nile Virus
|
| Published in |
Methods in molecular biology, January 2016
|
| DOI | 10.1007/978-1-4939-3670-0_1 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-3668-7, 978-1-4939-3670-0
|
| Authors |
Londono-Renteria, Berlin, Colpitts, Tonya M, Berlin Londono-Renteria, Tonya M. Colpitts, Berlin Londono, Colpitts, Tonya M. |
| Abstract |
West Nile virus (WNV) is an arbovirus with increased global incidence in the last decade. It is also a major cause of human encephalitis in the USA. WNV is an arthropod-transmitted virus that mainly affects birds but humans become infected as incidental dead-end hosts which can cause outbreaks in naïve populations. The main vectors of WNV are mosquitoes of the genus Culex, which preferentially feed on birds. As in many other arboviruses, the characteristics that allow Flaviviruses like WNV to replicate and transmit to different hosts are encrypted in their genome, which also contains information for the production of structural and nonstructural proteins needed for host cell infection. WNV and other Flaviviruses have developed different strategies to establish infection, replication, and successful transmission. Most of these strategies include the diversion of the host's immune responses away from the virus. In this review, we describe the molecular structure and protein function of WNV with emphasis on protein involvement in the modulation of antiviral immune responses. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 33% |
| Brazil | 1 | 17% |
| Unknown | 3 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 40 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 15% |
| Student > Ph. D. Student | 4 | 10% |
| Student > Bachelor | 3 | 8% |
| Student > Postgraduate | 3 | 8% |
| Student > Doctoral Student | 1 | 3% |
| Other | 5 | 13% |
| Unknown | 18 | 45% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 4 | 10% |
| Biochemistry, Genetics and Molecular Biology | 4 | 10% |
| Medicine and Dentistry | 4 | 10% |
| Immunology and Microbiology | 4 | 10% |
| Environmental Science | 1 | 3% |
| Other | 4 | 10% |
| Unknown | 19 | 48% |