Chapter title |
Serum Vitamin D and Immunogenicity of Influenza Vaccination in the Elderly
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Chapter number | 580 |
Book title |
Medical Research and Innovation
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Published in |
Advances in experimental medicine and biology, September 2020
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DOI | 10.1007/5584_2020_580 |
Pubmed ID | |
Book ISBNs |
978-3-03-070205-2, 978-3-03-070206-9
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Authors |
Sławin, Agata, Brydak, Lidia B, Doniec, Zbigniew, Bujnowska-Fedak, Maria, Mastalerz-Migas, Agnieszka, Agata Sławin, Lidia B. Brydak, Zbigniew Doniec, Maria Bujnowska-Fedak, Agnieszka Mastalerz-Migas, Brydak, Lidia B. |
Abstract |
Vaccination is the most effective preventive measure that reduces the risk of influenza and post-influenza complications. It prevents influenza-related hospitalizations and deaths in 50-60% and about 80% of patients aged over 65, respectively. There is the clinical plausibility of the association between serum vitamin D (VIT D) content and viral respiratory infections. In this study, we addressed the issue of a vitamin D modulatory effect on the immune response to seasonal influenza vaccination in elderly persons. The study comprised 96 participants aged 60-75 during the 2016/17 epidemic season. After the determination of the baseline content of VIT D and anti-hemagglutinin antibodies (H1, H3, and HB), participants were vaccinated with a trivalent vaccine. The content of the anti-hemagglutinin antibodies was rechecked 4-5 weeks afterward, showing inappreciable alterations. The negative findings of this study make the influence of serum VIT D content on the immunogenicity of influenza vaccination highly unlikely in elderly persons. |
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Members of the public | 2 | 100% |
Mendeley readers
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Student > Bachelor | 2 | 13% |
Student > Ph. D. Student | 2 | 13% |
Researcher | 2 | 13% |
Student > Master | 1 | 7% |
Professor > Associate Professor | 1 | 7% |
Other | 0 | 0% |
Unknown | 7 | 47% |
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Psychology | 1 | 7% |
Sports and Recreations | 1 | 7% |
Medicine and Dentistry | 1 | 7% |
Other | 0 | 0% |
Unknown | 8 | 53% |