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Porous silicon-based nanostructured microparticles as degradable supports for solid-phase synthesis and release of oligonucleotides

Overview of attention for article published in Discover Nano, July 2012
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Title
Porous silicon-based nanostructured microparticles as degradable supports for solid-phase synthesis and release of oligonucleotides
Published in
Discover Nano, July 2012
DOI 10.1186/1556-276x-7-385
Pubmed ID
Authors

Steven J P McInnes, Nicolas H Voelcker

Abstract

We describe the preparation of several types of porous silicon (pSi) microparticles as supports for the solid-phase synthesis of oligonucleotides. The first of these supports facilitates oligonucleotide release from the nanostructured support during the oligonucleotide deprotection step, while the second type of support is able to withstand the cleavage and deprotection of the oligonucleotides post synthesis and subsequently dissolve at physiological conditions (pH = 7.4, 37°C), slowly releasing the oligonucleotides. Our approach involves the fabrication of pSi microparticles and their functionalisation via hydrosilylation reactions to generate a dimethoxytrityl-protected alcohol on the pSi surface as an initiation point for the synthesis of short oligonucleotides.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Australia 2 11%
Italy 1 6%
United States 1 6%
Unknown 14 78%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 39%
Professor > Associate Professor 3 17%
Professor 2 11%
Student > Ph. D. Student 2 11%
Student > Master 1 6%
Other 2 11%
Unknown 1 6%
Readers by discipline Count As %
Chemistry 6 33%
Engineering 6 33%
Agricultural and Biological Sciences 2 11%
Materials Science 2 11%
Physics and Astronomy 1 6%
Other 0 0%
Unknown 1 6%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 July 2012.
All research outputs
#22,760,732
of 25,374,917 outputs
Outputs from Discover Nano
#798
of 1,146 outputs
Outputs of similar age
#160,925
of 177,928 outputs
Outputs of similar age from Discover Nano
#19
of 46 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,146 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 177,928 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.