Chapter title |
Tandem Repeats in Genes, Proteins, and Disease
|
---|---|
Chapter number | 16 |
Book title |
Tandem Repeats in Genes, Proteins, and Disease
|
Published in |
Methods in molecular biology, January 2013
|
DOI | 10.1007/978-1-62703-438-8_16 |
Pubmed ID | |
Book ISBNs |
978-1-62703-437-1, 978-1-62703-438-8
|
Authors |
Ross, Eric D, Maclea, Kyle S, Anderson, Charles, Ben-Hur, Asa, Eric D. Ross, Kyle S. MacLea, Charles Anderson, Asa Ben-Hur |
Abstract |
Numerous proteins contain domains that are enriched in glutamine and asparagine residues, and aggregation of some of these proteins has been linked to both prion formation in yeast and a number of human diseases. Unfortunately, predicting whether a given glutamine/asparagine-rich protein will aggregate has proven difficult. Here we describe a recently developed algorithm designed to predict the aggregation propensity of glutamine/asparagine-rich proteins. We discuss the basis for the algorithm, its limitations, and usage of recently developed online and downloadable versions of the algorithm. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 5% |
Unknown | 21 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 36% |
Student > Ph. D. Student | 5 | 23% |
Professor > Associate Professor | 3 | 14% |
Professor | 2 | 9% |
Student > Master | 1 | 5% |
Other | 1 | 5% |
Unknown | 2 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 9 | 41% |
Agricultural and Biological Sciences | 7 | 32% |
Neuroscience | 2 | 9% |
Immunology and Microbiology | 1 | 5% |
Computer Science | 1 | 5% |
Other | 0 | 0% |
Unknown | 2 | 9% |