| Chapter title |
Characterizing social behavior in genetically targeted mouse models of brain disorders.
|
|---|---|
| Chapter number | 7 |
| Book title |
Tandem Repeats in Genes, Proteins, and Disease
|
| Published in |
Methods in molecular biology, January 2013
|
| DOI | 10.1007/978-1-62703-438-8-7 |
| Pubmed ID | |
| Book ISBNs |
978-1-62703-437-1, 978-1-62703-438-8
|
| Authors |
Burrows, Emma L, Hannan, Anthony J, Emma L. Burrows, Anthony J. Hannan |
| Editors |
Danny M. Hatters, Anthony J. Hannan |
| Abstract |
Fragile X syndrome, the leading inherited cause of mental retardation and autism spectrum disorders worldwide, is caused by a tandem repeat expansion in the FMR1 (fragile X mental retardation 1) gene. It presents with a distinct behavioral phenotype which overlaps significantly with that of autism. Emerging evidence suggests that tandem repeat polymorphisms (TRPs) might also play a key role in modulating disease susceptibility for a range of common polygenic disorders, including the broader autism spectrum of disorders (ASD) and other forms of psychiatric illness such as schizophrenia, depression, and bipolar disorder [1]. In order to understand how TRPs and associated gene mutations mediate pathogenesis, various mouse models have been generated. A crucial step in such functional genomics is high-quality behavioral and cognitive phenotyping. This chapter presents a basic behavioral battery for standardized tests for assaying social phenotypes in mouse models of brain disorders, with a focus on aggression. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 8% |
| Unknown | 12 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 77% |
| Student > Master | 7 | 54% |
| Student > Ph. D. Student | 6 | 46% |
| Student > Bachelor | 3 | 23% |
| Professor | 3 | 23% |
| Other | 7 | 54% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 11 | 85% |
| Psychology | 11 | 85% |
| Agricultural and Biological Sciences | 6 | 46% |
| Medicine and Dentistry | 5 | 38% |
| Biochemistry, Genetics and Molecular Biology | 1 | 8% |
| Other | 1 | 8% |