Advances in Down Syndrome Research

Chapter 2 Predicting pathway perturbations in Down syndrome

Chapter 3 Aberrant protein expression of transcription factors BACH1 and ERG, both encoded on chromosome 21, in brains of patients with Down syndrome and Alzheimer's disease.

Chapter 4 Cell cycle and cell size regulation in Down Syndrome cells

Chapter 5 Transcription factor REST dependent proteins are comparable between Down Syndrome and control brains: challenging a hypothesis

Chapter 6 An altered antioxidant balance occurs in Down syndrome fetal organs: Implications for the “gene dosage effect” hypothesis

Chapter 7 Overexpression of C1-tetrahydrofolate synthase in fetal Down Syndrome brain

Chapter 8 Increased expression of human reduced folate carrier in fetal Down syndrome brain

Chapter 9 Chromosome 21 KIR channels in brain development

Chapter 10 Reduction of chromatin assembly factor 1 p60 and C21orf2 protein, encoded on chromosome 21, in Down syndrome brain.

Chapter 11 The MNB/DYRK1A protein kinase: Neurobiological functions and Down syndrome implications

Chapter 12 The MNB/DYRK1A protein kinase: genetic and biochemical properties.

Chapter 13 Cytoskeleton derangement in brain of patients with Down Syndrome, Alzheimer’s disease and Pick’s disease

Chapter 14 The cerebral cortex in Fetal Down Syndrome

Chapter 15 Polysomnography in transgenic hSOD1 mice as Down syndrome model

Chapter 16 Spectrum of cognitive, behavioural and emotional problems in children and young adults with Down syndrome

Chapter 17 Overexpression of transcription factor BACH1 in fetal Down syndrome brain.

Chapter 18 Down syndrome and associated congenital malformations

Chapter 19 RNA Microarray analysis of channels and transporters in normal and fetal Down Syndrome (trisomy 21) brain

Chapter 20 Heart type fatty acid binding protein (H-FABP) is decreased in brains of patients with Down syndrome and Alzheimer’s disease

Chapter 21 Stem cell marker expression in human trisomy 21 amniotic fluid cells and trophoblasts