Protein Allostery in Drug Discovery

Chapter 1 Allostery in Drug Development

Chapter 2 Dynamic Protein Allosteric Regulation and Disease

Chapter 3 Protein Allostery in Rational Drug Design

Chapter 4 Progress in Allosteric Database

Chapter 5 Correlation Between Allosteric and Orthosteric Sites

Chapter 6 Characteristics of Allosteric Proteins, Sites, and Modulators

Chapter 7 Advances in the Computational Identification of Allosteric Sites and Pathways in Proteins

Chapter 8 Advances in NMR Methods to Identify Allosteric Sites and Allosteric Ligands

Chapter 9 Interrogating Regulatory Mechanisms in Signaling Proteins by Allosteric Inhibitors and Activators: A Dynamic View Through the Lens of Residue Interaction Networks

Chapter 10 GPCR Allosteric Modulator Discovery

Chapter 11 Allosteric Small-Molecule Serine/Threonine Kinase Inhibitors

Chapter 12 Allosteric Regulation of Protein Kinases Downstream of PI3-Kinase Signalling

Chapter 13 Allosteric Modulators of Protein–Protein Interactions (PPIs)

Chapter 14 Allosteric Modulation of Intrinsically Disordered Proteins